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搜索结果：“MK 1775”

“MK 1775”的搜索结果

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Staurosporine

Catalog No. A10864
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PKC 抑制剂

Staurosporine是一种天然产物，最初于1977年从Streptomyces staurosporeus细菌中分离出来。星形孢菌素的主要生物学活性是通过防止ATP与激酶的结合来抑制蛋白激酶。是一种有效的PKC抑制剂，在无细胞试验中作用于PKCα，PKCγ 和PKCη，IC50分别为2 nM，5 nM 和 4 nM，对PKCδ(20 nM)和PKCε(73 nM作用较弱，对PKCζ (1086 nM)的活性很低。同时对其他的激酶PKA, PKG, S6K, CaMKII, 等也显示抑制活性。了解更多

Product Citations (3)

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- Lisa M Kim, .et al. Sustained Oncogenic Signaling in the Cytostatic State Enables Targeting of Nonproliferating Persistent Cancer Cells, Cancer Res, 2022, Sep 2;82(17):3045-3057 PMID: 35792658
- Jacobs CL, .et al. StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins, Nat Methods, 2018, Jul;15(7):523-526 PMID: 29967496
- Birte Plitzko, .et al. The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells, J Biol Chem, 2017, Dec 22; 292(51): 21102-21116 PMID: 29074620
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Glycyl-H 1152 2HCl

Catalog No. A13659
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ROCK 抑制剂

Glycyl-H 1152 2HCl是一种选择性有效的ROCK抑制剂（ROCKII，Aurora A，CAMKII，PKG，PKA和PKC的IC50值分别为0.0118、2.35、2.57、3.26，> 10和> 10 uM。）了解更多

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LX7101

Catalog No. A16211
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LIMK2 抑制剂

LX7101是基于吡咯并嘧啶的局部递送的LIM域激酶2（LIMK2）抑制剂，LIM域激酶2是与眼内压调节相关的激酶。了解更多

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BMS-5

Catalog No. A12839
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LIMK 抑制剂

BMS-5是一种有效的LIMK抑制剂，对LIMK1和LIMK2的IC50分别为7 nM和8 nM。了解更多

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R-10015

Catalog No. A18806
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LIMK inhibitor

R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1. 了解更多

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T56-LIMKi

Catalog No. A12266
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LIMK2 inhibitor

T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. 了解更多

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BMS-3

Catalog No. A20999
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LIMK inhibitor

BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. 了解更多

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