“bone morphogenetic proteins bmp”的搜索结果
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p53-MDM2 interaction 抑制剂
p53和MDM2蛋白相互作用抑制剂消旋体是p53和MDM2蛋白之间相互作用的抑制剂。
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p53-MDM2 interaction 抑制剂
p53和MDM2蛋白相互作用抑制剂手性是p53和MDM2蛋白之间相互作用的抑制剂。
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BMP type I receptor inhibitor
LDN193189 Tetrahydrochloride is a selective BMP type I receptor inhibitor, which efficiently inhibits ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on ALK4, ALK5 and ALK7 (IC50??500 nM).
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Calcium channel proteins inhibitor
Dantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction.
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BMP 抑制剂
Dorsomorphin 2HCl (BML-275)是BMP信号传导的选择性小分子抑制剂,可促进胚胎干细胞的心肌发生。Dorsomorphin通过抑制骨形态发生蛋白信号转导逆转乳腺癌起始细胞的间质表型。
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- Kameshima S, .et al. Eukaryotic elongation factor 2 (eEF2) kinase/eEF2 plays protective roles against glucose deprivation-induced cell death in H9c2 cardiomyoblasts, Apoptosis, 2019, Feb 8 PMID: 30737648
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BMP 抑制剂
K02288是一种有效的选择性I型BMP受体抑制剂,对ALK2,ALK1和ALK6的IC50为1.1、1.8、6.4 nM。
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BMP receptor 抑制剂
ML347是一种选择性BMP受体抑制剂。
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BMP receptor 抑制剂
LDN-212854是一种ALK2偏爱的BMP I型受体激酶抑制剂。
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ALK2 抑制剂
DMH-1是骨形态发生蛋白(BMP)ALK2受体的选择性抑制剂(IC50 = 108 nM)。
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- Teresa Rayon, .et al. Species-specific pace of development is associated with differences in protein stability, Science, 2020, Sep 18;369(6510):eaba7667 PMID: 32943498
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osteoclastic bone resorption 抑制剂
Zoledronic acid, 破骨细胞抑制剂,通过抑制甲羟戊酸途径诱导破骨细胞凋亡。
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HSP90??/HSP90?? inhibitor
TAS-116 is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity.
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nuclear export receptor CRM1 inhibitor
Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle.
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HCV NS5B RNA-dependent RNA polymerase inhibitor
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM.
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IDH inhibitor
Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.
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SREBP inhibitor
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
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Bromodomain inhibitor
BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins.
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RGS inhibitor
CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.
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BET inhibitor
(S)-JQ-35 (TEN-010) is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity.
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cell motility and cell invasion inhibitor
KBU2046 is an oral, highly selective inhibitor of cell motility and cell invasion in vitro. KBU2046 binds chaperone heterocomplexes, selectively alters binding of client proteins that regulate motility, and lacks all of the hallmarks of classical HSP90 inhibitors. KBU2046 inhibits cancer metastasis and prolongs life.
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D2DR inhibitor
Promazine Hydrochloride is a phenothiazine compound and D2DR inhibitor. Promazine Hydrochloride has been employed in studies investigating dopamine-stimulated glycosylation of brain proteins in vitro. It has actions similar to chlorpromazine but with less antipsychotic activity.
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Mcl-1 inhibitor
Mcl1-IN-1 is a potent and selective inhibitor of the apoptosis regulating proteins Mcl-1.
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ENT1 抑制剂
NBMPR是一种核苷类似物,可竞争性抑制平衡的核苷转运蛋白1(大鼠和人的Kd = 0.1-1.0 nM,IC50s = 4.6和3.6 nM)。
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ALK 抑制剂
LDN193189是一种高效的小分子BMP抑制剂,可抑制BMP I型受体ALK2(IC50=5 nM),ALK3(IC50=30 nM)和ALK6(TGFβ1/BMP信号转导)以及随后的SMAD磷酸化。
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- Trang Thi Huyen Dang, .et al. BMP10 positively regulates myogenic differentiation in C2C12 myoblasts via the Smad 1/5/8 signaling pathway, Mol Cell Biochem, 2021, May;476(5):2085-2097 PMID: 33517521
- Shizu Aikawa, .et al. Autotaxin-lysophosphatidic acid-LPA 3 signaling at the embryo?\epithelial boundary controls decidualization pathways, EMBO J, 2017, Jul 14; 36(14): 2146-2160 PMID: 28588064
- HIROTAKA SOMEYA, .et al. Thymosin beta 4 is associated with RUNX2 expression through the Smad and Akt signaling pathways in mouse dental epithelial cells, Int J Mol Med, 2015, May; 35(5): 1169-1178 PMID: 25739055
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TGF-beta/Smad 抑制剂
GW788388是有效的,口服活性的,选择性的转化生长因子β受体I(TGF-βR1)(激活素受体样激酶5,ALK5)抑制剂,无细胞试验中IC50为18 nM,也抑制TGF-βII型受体和activin II型受体活性,但不抑制BMP II型受体。
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