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Indotecan

Catalog No. A20979
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Top1 inhibitor

Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. 了解更多

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MAC glucuronide phenol-linked SN-38

Catalog No. A18403
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DNA topoisomerase I inhibitor

MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively. 了解更多

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Amsacrine hydrochloride

Catalog No. A17707
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antineoplastic agent

Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells. 了解更多

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Rubitecan

Catalog No. A22040
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topoisomerase I inhibitor

Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. 了解更多

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Dexrazoxane

Catalog No. A17714
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topoisomerase IIα inhibitor

Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. 了解更多

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