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搜索结果：“CFTR”

“CFTR”的搜索结果

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PTC124 (Ataluren)

Catalog No. A10758
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CFTR 抑制剂

PTC124也称为Ataluren，是CFTR-G542X无意义等位基因抑制剂。了解更多

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- L Kadunc, .et al. Increased Gene Translation Stringency in Mammalian Cells by Nonsense Suppression at Multiple Permissive Sites With a Single Noncanonical Amino Acid, FEBS Lett, 2020, May 13 PMID: 32401336
- Caspi M, .et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents, J Mol Med (Berl), 2016, Apr;94(4):469-82 PMID: 26620677
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Oridonin (Isodonol)

Catalog No. A10675
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CFTR 抑制剂

Oridonin (Isodonol)是一种从鼠李木中分离出来的Entkaurane二萜类化合物，是一种重要的传统中草药。了解更多

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Glyburide

Catalog No. A10433
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K+ channel and CFTR Cl- channel blocker

Glyburide (Glibenclamide) 是一种抗糖尿病化合物，是一类磺脲类药物。了解更多

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PPQ-102

Catalog No. A13000
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CFTR chloride channel 抑制剂

PPQ-102是一种化合物，其靶向cftr的胞内核苷酸结合结构域，并以电压依赖性和可逆的方式抑制cftr介导的氯离子电流。了解更多

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KM 11060

Catalog No. A15843
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F508del-CFTR trafficking corrector

KM 11060纠正了F508del-CFTR的运输，增加了质膜上功能性CFTR的量（?75％）并抑制了PDE5的活性。了解更多

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VX-770 (Ivacaftor)

Catalog No. A10985
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CFTR activator

VX-770 (Ivacaftor)被称为CFTR增强剂，靶向作用于G551D-CFTR和F508del-CFTR，在fisher大鼠甲状腺细胞中EC50分别为100 nM和25 nM。了解更多

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- Okiyoneda T, .et al. Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase, Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
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VX-809 (Lumacaftor)

Catalog No. A10986
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CFTR modulator

VX-809 (Lumacaftor)是用于治疗囊性纤维化（CF）的第二种口服研究候选化合物，通过促进突变型CFTR(F508del-CFTR)的成熟，从而纠正囊性纤维症中常见的CFTR突变，在fisher大鼠甲状腺细胞中EC50为0.1 μM。了解更多

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- Kusumika Saha, .et al. Pharmacological chaperone-rescued cystic fibrosis CFTR-F508del mutant overcomes PRAF2-gated access to endoplasmic reticulum exit sites, Cell Mol Life Sci, 2022, Sep 27;79(10):530 PMID: 36167862
- Heledd H Jarosz-Griffiths, .et al. Different CFTR Modulator Combinations Downregulate Inflammation Differently in Cystic Fibrosis, Elife, 2020, Mar 2;9:e54556 PMID: 32118580
- Okiyoneda T, .et al. Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase, Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
- Junko Kido, .et al. Cystic Fibrosis Transmembrane Conductance Regulator Reduces Microtubule-Dependent Campylobacter jejuni Invasion, Infect Immun, 2017, Oct; 85(10): e00311-17 PMID: 28784926
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CFTRinh-172

Catalog No. A12897
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CFTR 抑制剂

CFTRinh-172是电压无关的选择性CFTR抑制剂。在2分钟内可逆地抑制CFTR短路电流的 Ki 值为300 nM。了解更多

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- Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851
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CFTR-Inhibitor-II

Catalog No. A13723
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CFTR 抑制剂

CFTR inhibitor II,也称为GlyH-101，是一种甘氨酸酰肼，可选择性和可逆地阻断CFTR通道（Ki = 4.3 uM）。了解更多

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- Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851