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产品 1 到 50 共 62个

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  1. SKF 89976A HCl

    Catalog No. A10849
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    GABA uptake 抑制剂
    SKF 89976A HCl是一种有效的GABA吸收抑制剂,hGAT-1,rGAT-2,hGAT-3和hBGT-1的IC50分别为0.13、550、944和7210μM。 了解更多
  2. Vilazodone

    Catalog No. A11116
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    Serotonin reuptake 抑制剂
    Vilazodone充当5-羟色胺再摄取抑制剂(IC50 = 0.5 nM)和5-HT1A受体部分激动剂(IC50 = 0.2 nM; IA =?60-70%)。 了解更多
  3. Vanoxerine 2HCl (GBR-12909)

    Catalog No. A10725
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    dopamine re-uptake 抑制剂
    Vanoxerine 2HCl (GBR-12909)是哌嗪衍生物,是一种有效的、选择性的多巴胺摄取(dopamine uptake)抑制剂。 了解更多
  4. Diclofensine

    Catalog No. A10305
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    Monoamine reuptake 抑制剂
    Diclofensine (Ro 8-4650)用作三重单胺再摄取抑制剂,主要抑制多巴胺和去甲肾上腺素的再摄取。 了解更多
  5. Maprotiline hydrochloride

    Catalog No. A10555
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    noradrenalin re-uptake 抑制剂
    Maprotiline hydrochloride是选择性去甲肾上腺素再摄取抑制剂。 了解更多
  6. GBR 12783 dihydrochloride

    Catalog No. A13128
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    dopamine uptake 抑制剂
    GBR 12783 dihydrochloride是一种非常有效的选择性多巴胺摄取抑制剂(抑制大鼠纹状体突触体中[3H]-多巴胺摄取的IC50为1.8 nM)。 了解更多
  7. Levomilnacipran HCl

    Catalog No. A14391
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    serotonin/NE reuptake 抑制剂
    Levomilnacipran HCl是一种选择性的5-羟色胺和去甲肾上腺素再摄取抑制剂。 了解更多
  8. Edivoxetine HCl

    Catalog No. A13865
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    norepinephrine reuptake 抑制剂
    Edivoxetine HCl是一种选择性去甲肾上腺素再摄取抑制剂。 了解更多
  9. Guvacine hydrochloride

    Catalog No. A13613
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    GABA uptake 抑制剂
    Guvacine hydrochloride可抑制GABA的摄取(hGABA T-1,rGABA T-2,hGABA T-3和hBGT-1的IC50值分别为14、58、119和1870 uM)。 了解更多
  10. Norfluoxetine

    Catalog No. A13458
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    serotonin uptake 抑制剂
    Norfluoxetine是抗抑郁药氟西汀的活性代谢物,抑制5-羟色胺的摄取,pKi值为7.35.1氟西汀的S-对映体的5-羟色胺再摄取阻断能力是R-对映体的20倍(pKis分别为7.86和6.51)。 了解更多
  11. Nisoxetine hydrochloride

    Catalog No. A13418
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    Noradrenalin re-uptake 抑制剂
    Nisoxetine hydrochloride是去甲肾上腺素转运蛋白的选择性强抑制剂,对一系列其他神经递质受体几乎没有或没有亲和力。Nisoxetine hydrochloride是SLC6A2的抑制剂。 了解更多
  12. Bitopertin

    Catalog No. A15021
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    Glycine reuptake 抑制剂
    Bitopertin是一种有效的非竞争性甘氨酸再摄取抑制剂(GlyT1)。 了解更多
  13. Bitopertin (R enantiomer)

    Catalog No. A15022
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    Glycine reuptake 抑制剂
    Bitopertin (R enantiomer)是一种有效的非竞争性甘氨酸再摄取抑制剂(GlyT1)。 了解更多
  14. NG25

    Catalog No. A15185
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    TAK1/MAP4K2 抑制剂
    NG25和TAK1抑制TLR7和TLR9激动剂激活IKK,并阻止Gen2.2细胞中这些配体诱导的1型IFN分泌。 了解更多
  15. Phenylpiracetam

    Catalog No. A15211
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    Dopamine reuptake 抑制剂
    Phenylpiracetam是促智药物吡乙酰胺的苯基化衍生物。它被用作促智药物,效力比吡乙酰胺高30-60倍。 了解更多
  16. Azaphen dihydrochloride monohydrate

    Catalog No. A15009
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    serotonin reuptake 抑制剂
    Azaphen dihydrochloride monohydrate是5-羟色胺再摄取的有效抑制剂。 了解更多
  17. Desvenlafaxine succinate hydrate

    Catalog No. A15491
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    serotonin (5-HT)/norepinephrine (NE) reuptake 抑制剂
    Desvenlafaxine succinate hydrate是一种新型5-羟色胺(5-HT)转运蛋白 和去甲肾上腺素(NE)转运蛋白重吸收抑制剂,Ki值分别为40.2 nM和558.4 nM 了解更多
  18. MCI-225

    Catalog No. A15502
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    NA reuptake 抑制剂
    MCI-225是具有5-HT3受体拮抗作用的选择性NA再摄取抑制剂。 了解更多
  19. Tiagabine

    Catalog No. A13198
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    GABA reuptake 抑制剂
    Tiagabine是一种选择性γ-氨基丁酸(gaba)再摄取抑制剂。 了解更多
  20. Tiagabine hydrochloride

    Catalog No. A16135
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    GABA reuptake 抑制剂
    Tiagabine hydrochloride是一种抗惊厥药。该药物还用于治疗惊恐症,还有其他一些抗惊厥药。 了解更多
  21. YL-0919

    Catalog No. A16337
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    5-HT1A receptor 激动剂/serotonin reuptake 抑制剂
    YL0919,具有5-HT1A受体激动剂和选择性5-羟色胺再摄取抑制剂双重活性的新型抗抑郁候选药物,YL-0919抑制5-HT被大鼠大脑皮层突触小体和人重组细胞摄取的IC50值为1.78±0.34 nM和1.93±0.18 nM。 了解更多
  22. Takinib

    Catalog No. A16960
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    TAK1 抑制剂
    Takinib是一种选择性的TAK1抑制剂,在类风湿性关节炎和转移性乳腺癌的细胞模型中,TNF-α刺激后可诱导细胞凋亡。 了解更多
  23. Paroxetine mesylate

    Catalog No. A17566
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    serotonin uptake inhibitor
    Paroxetine Mesylate is a serotonin uptake inhibitor that is effective in the treatment of depression. 了解更多
  24. Amezinium methylsulfate

    Catalog No. A18103
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    norepinephrine reuptake inhibitor
    Amezinium Metilsulfate, also known as Regulton and LU-1631, is a norepinephrine reuptake inhibitor which exclusively affects postganglionic sympathetic neurons. Amezinium Metilsulfate is used to treat hypotension. 了解更多
  25. DMT1 blocker 2

    Catalog No. A18999
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    DMT1 inhibitor
    DMT1 blocker 2, Compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 of 0.83 μM, is expected to block iron uptake by enterocytes in vivo. 了解更多
  26. NBTGR

    Catalog No. A13489
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    Nucleoside transport inhibitor
    NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a Ki of 70 nM. 了解更多
  27. Escitalopram oxalate

    Catalog No. A16533
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    Serotonin reuptake inhibitor
    Escitalopram oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM. 了解更多
  28. VU 0240551

    Catalog No. A20854
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    KCC2 inhibitor
    VU 0240551 is a small molecule inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 560 nM for K+ uptake assay in KCC2-overexpressing cells). 了解更多
  29. Diclofensine hydrochloride

    Catalog No. A20923
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    monoamine reuptake inhibitor
    Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively. 了解更多
  30. Escitalopram

    Catalog No. A21241
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    selective serotonin reuptake inhibitor (SSRI)
    Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM. 了解更多
  31. Dasotraline

    Catalog No. A21618
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    triple reuptake inhibitor
    Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. 了解更多
  32. Dasotraline hydrochloride

    Catalog No. A21684
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    triple reuptake inhibitor
    Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. 了解更多
  33. LY2365109 hydrochloride

    Catalog No. A21779
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    GlyT1 inhibitor
    LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a. 了解更多
  34. Vilazodone D8

    Catalog No. A21876
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    SSR inhibitor / 5-HT1A receptor partial agonist
    Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. 了解更多
  35. Vanoxerine

    Catalog No. A21922
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    dopamine reuptake inhibitor
    Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). 了解更多
  36. Eplivanserin mixture

    Catalog No. A21987
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    serotonin reuptake inhibitor/5-HT2A receptor antagonist
    Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1. 了解更多
  37. GBR 12935

    Catalog No. A21951
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    dopamine reuptake inhibitor
    GBR 12935 is a potent, and selective dopamine reuptake inhibitor. 了解更多
  38. Cenicriviroc

    Catalog No. A13643
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    CCR2/CCR5 抑制剂
    Cenicriviroc是用于治疗HIV感染的实验性候选药物.Cenicriviroc是CCR2和CCR5受体的抑制剂,可使其充当阻止病毒进入人体细胞的进入抑制剂。 了解更多
  39. Lapaquistat

    Catalog No. A21262
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    cholesterol biosynthesis inhibitor
    Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of TAK-475. Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy. 了解更多
  40. MLN1117 (Serabelisib)

    Catalog No. A15529
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    p110α 抑制剂
    MLN1117,也称为INK1117和TAK-117,是具有潜在抗肿瘤活性的I类磷酸肌醇3激酶(PI3K)α同工型的生物利用抑制剂。 了解更多
  41. Cenicriviroc Mesylate

    Catalog No. A17028
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    CCR2/5 receptors 抑制剂
    Cenicriviroc(TAK-652,TBR-652)是CCR2和CCR5受体的抑制剂,可使其充当防止病毒进入人细胞的进入抑制剂 了解更多
  42. Resatorvid

    Catalog No. A11543
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    TLR4 inhibitor
    Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor and plays pivotal role in various inflammatory diseases. 了解更多
  43. Lapaquistat acetate

    Catalog No. A20851
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    squalene synthase inhibitor
    Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene. 了解更多
  44. (R)-Simurosertib

    Catalog No. A21894
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    CDC7 kinase inhibitor
    (R)-Simurosertib ((R)-TAK-931) is the (R)-enantiomer of Simurosertib, Simurosertib (TAK-931) is a selective cycle 7 (CDC7) kinase inhibitor, with an IC50<0.3 nM. 了解更多
  45. Mubritinib (TAK 165)

    Catalog No. A10612
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    HER2/ErbB2 抑制剂
    Mubritinib (TAK 165)是一种有效的EGFR和p34cdc2抑制剂,IC50分别为6 nM和0.2 ?M。Mubritinib(TAK 165)也抑制p33cdk2和p33cdk5。 了解更多
  46. TAK-700 (Orteronel)

    Catalog No. A11044
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    CYP17A1 抑制剂
    TAK-700 (Orteronel)是一种口服非甾体雄激素合成抑制剂,可选择性抑制17,20裂解酶。 了解更多
  47. TAK-960

    Catalog No. A11146
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    PLK1 抑制剂?
    TAK-960是新型的,口服可用的polo样激酶1选择性抑制剂,具有广谱的临床前抗肿瘤活性。 了解更多
  48. TAK-441

    Catalog No. A11351
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    Hedgehog 抑制剂
    TAK-441是吡咯并[3,2-c]吡啶衍生物,作为高效口服活性hedgehog信号抑制剂。 了解更多
  49. TAK-593

    Catalog No. A13555
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    VEGFR/PDGFR 抑制剂
    TAK-5933是一种口服制剂,其中含有血管内皮生长因子受体(VEGFR)和血小板衍生生长因子受体(PDGFR)的小分子受体酪氨酸激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多
  50. TAK-063

    Catalog No. A15799
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    PDE10A 抑制剂?
    TAK-063是一种高效,选择性和口服活性的PDE10A抑制剂,IC50为0.30 nM。选择性是其他PDE的15000倍以上。 了解更多

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