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  • 搜索结果：“jwh 250”

“jwh 250”的搜索结果

产品 51 到 84 共 84个

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  1. Safinamide
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    Safinamide

    Catalog No. A13294
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    MAO-B 抑制剂
    Safinamide是一种高度选择性和可逆的B型单胺氧化酶（MAO-B）抑制剂，可增加新纹状体多巴胺的浓度。 了解更多
  2. FIPI
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    FIPI

    Catalog No. A13895
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    PLD 抑制剂
    FIPI是卤胺的衍生物，可有效抑制PLD1（IC50 = 25 nM）和PLD2（IC50 = 20 nM）。 了解更多
  3. Pitavastatin Lactone
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    Pitavastatin Lactone

    Catalog No. A13896
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    HMG-CoA reductase 抑制剂
    Pitavastatin Lactone是HMG-CoA还原酶抑制剂。 了解更多
  4. JW-642
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    JW-642

    Catalog No. A13774
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    MAGL 抑制剂
    JW-642是有效的单酰基甘油脂肪酶（MAGL）抑制剂，对小鼠，大鼠和人脑膜的MAGL抑制作用的IC50值分别为7.6、14和3.7 nM。 了解更多
  5. RN-1 2HCl
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    RN-1 2HCl

    Catalog No. A14344
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    MAO 抑制剂
    RN-1 2HCl对LSD1的选择性优于单胺氧化酶(MAO)-A和MAO-B（在辣根过氧化物酶偶联测定中，IC50值分别为70 nM，0.51和2.79 μM）。 了解更多
  6. Monoammoniumglycyrrhizinate
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    Monoammoniumglycyrrhizinate

    Catalog No. A14599
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    Monoammoniumglycyrrhizinate是甘草根的一种成分，具有重要的抗病毒活性，已显示可通过间接机制抑制11_αHSD2（11_α羟类固醇脱氢酶2型）的表达。 了解更多
  7. (24R)-MC 976
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    (24R)-MC 976

    Catalog No. A14960
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    (24R)-MC 976是维生素D3衍生物。 了解更多
  8. (24S)-MC 976
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    (24S)-MC 976

    Catalog No. A14962
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    (24S)-MC 976是维生素D3衍生物。 了解更多
  9. 1alpha, 24, 25-Trihydroxy VD2
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    1alpha, 24, 25-Trihydroxy VD2

    Catalog No. A14968
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    1alpha, 24, 25-Trihydroxy VD2是维生素D类似物。 了解更多
  10. 1alpha-Hydroxy VD4
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    1alpha-Hydroxy VD4

    Catalog No. A14970
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    1alpha-Hydroxy VD4可有效诱导单核细胞白血病U937，P39/TSU和P31/FUJ细胞分化。 了解更多
  11. 24, 25-Dihydroxy VD3
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    24, 25-Dihydroxy VD3

    Catalog No. A14973
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    24, 25-Dihydroxy VD3是与维生素D3的活性形式1，25-二羟基维生素D3密切相关的化合物，但是与维生素D3本身和25-羟基维生素D3一样，其在体内和体外都没有作为激素的活性。 了解更多
  12. 3-O-(2-Aminoethyl)-25-hydroxyvitamin D3
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    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3

    Catalog No. A14977
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    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3是一种维生素D3衍生物。 了解更多
  13. GSK256066 2,2,2-trifluoroacetic acid
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    GSK256066 2,2,2-trifluoroacetic acid

    Catalog No. A15097
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    PDE 抑制剂
    GSK256066是一种选择性PDE4B（与A-D型同等亲和力）抑制剂，IC50为3.2 pM，对PDE1/2/3/5/6的选择性> 380,000倍，对PDE4B与PDE7的选择性> 2500倍。 了解更多
  14. Impurity B of Calcitriol
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    Impurity B of Calcitriol

    Catalog No. A15123
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    Impurity B of Calcitriol是维生素D的激素活性形式，骨化三醇是激活维生素D受体（VDR）的维生素D3的活性代谢产物。 了解更多
  15. Olprinone Hydrochloride
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    Olprinone Hydrochloride

    Catalog No. A15198
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    PDE3 抑制剂
    Olprinone Hydrochloride是一种选择性磷酸二酯酶3（PDE3）抑制剂。 了解更多
  16. VD2-D3
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    VD2-D3

    Catalog No. A15274
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    VD2-D3是维生素D的氘代形式。 了解更多
  17. Alvespimycin
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    Alvespimycin

    Catalog No. A14990
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    Hsp90 抑制剂
    Alvespimycin是一种选择性Hsp90抑制剂，GI50为53 nM。 了解更多
  18. SR9243
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    SR9243

    Catalog No. A15535
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    LXR 激动剂
    SR9243是有效的选择性LXR反向激动剂。SR9243通过抑制脂质产生和Warburg效应杀死癌细胞。它在多种类型的癌症中诱导细胞死亡，并且不会引起副作用，而这些副作用已使先前针对这些过程的尝试脱轨。 了解更多
  19. TAK-063
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    TAK-063

    Catalog No. A15799
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    PDE10A 抑制剂?
    TAK-063是一种高效，选择性和口服活性的PDE10A抑制剂，IC50为0.30 nM。选择性是其他PDE的15000倍以上。 了解更多
  20. 3PO
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    3PO

    Catalog No. A15932
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    PFKFB3 抑制剂
    3PO是PFKFB3（6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶）抑制剂。 了解更多
  21. NCT-501
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    NCT-501

    Catalog No. A15892
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    hALDH1 抑制剂?
    NCT-501是一种有效且选择性的醛脱氢酶1A1（ALDH1A1）抑制剂，IC50为40 nM。 了解更多
  22. KNK437
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    KNK437

    Catalog No. A14389
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    pan-HSP 抑制剂
    KNK437剂量依赖性地抑制了COLO 320DM（人类结肠癌）细胞中耐热性的获得以及各种HSP的诱导，包括HSP105，HSP70和HSP40。 了解更多
  23. D609
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    D609

    Catalog No. A11388
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    PC-PLC 抑制剂
    D609是选择性竞争性磷脂酰胆碱特异性磷脂酶C(PC-PLC)抑制剂(Ki = 6.4 μM)；抗病毒和抗肿瘤剂。 了解更多
  24. CAY10566
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    CAY10566

    Catalog No. A16936
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    SCD1 抑制剂
    CAY10566是SCD1的强效和选择性抑制剂，在小鼠和人酶测定中的IC50值分别为4.5和26 nM。 了解更多
  25. Vorasidenib
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    Vorasidenib

    Catalog No. A16908
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    IDH1 抑制剂
    Vorasidenib (AG-881)是一种有效且选择性的口服抑制剂，可抑制细胞质中异柠檬酸脱氢酶1型(IDH1，IDH1 [NADP+]可溶)和2型（IDH2异柠檬酸脱氢酶[NADP+]）的突变形式。线粒体中的线粒体，具有潜在的抗肿瘤活性。 了解更多
  26. SR9238
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    SR9238

    Catalog No. A15763
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    LXR Inverse 激动剂
    SR9238是有效的选择性LXR反向激动剂（LXRβ和LXRα的IC50值分别为43和214 nM）。 了解更多
  27. AMG-333
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    AMG-333

    Catalog No. A17182
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    TRPM8 拮抗剂
    AMG-333是有效的选择性TRPM8拮抗剂，IC50为13 nM。 了解更多
  28. Fondaparinux Sodium
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    Fondaparinux Sodium

    Catalog No. A17918
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    factor Xa inhibitor
    Fondaparinux sodium is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII). 了解更多
  29. BPN14770
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    BPN14770

    Catalog No. A18663
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    PDE4D inhibitor
    BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. 了解更多
  30. SBI-797812
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    SBI-797812

    Catalog No. A19058
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    NAMPT activator
    SBI-797812 is a novel NAMPT activator, elevating liver NAD+, turning NAMPT into a "super catalyst" that more efficiently generates NMN. 了解更多
  31. IDO-IN-12
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    IDO-IN-12

    Catalog No. A18988
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    IDO inhibitor
    IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO) inhibitor extracted from patent WO 2017181849 A1. 了解更多
  32. Bergaptol
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    Bergaptol

    Catalog No. A12303
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    CYP3A4 enzyme inhibitor
    Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties. 了解更多
  33. IACS-8968 R-enantiomer
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    IACS-8968 R-enantiomer

    Catalog No. A21555
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    dual IDO/TDO inhibitor
    IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多
  34. IACS-8968 S-enantiomer
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    IACS-8968 S-enantiomer

    Catalog No. A21559
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    dual IDO/TDO inhibitor
    IACS-8968 (S-enantiomer) is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多

产品 51 到 84 共 84个

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  1. Cytochrome P450 (7)
  2. PPAR (3)
  3. PDE (10)
  4. HSP (7)
  5. Hydroxylases (2)
  6. Factor Xa (1)
  7. MAO (4)
  8. Dehydrogenases (5)
  9. Carbonic Anhydrase (3)
  10. LXR (2)
  11. CETP (1)
  12. Ferroptosis (1)
  13. HMG-CoA Reductase (6)
  14. FXR (2)
  15. Isocitrate Dehydrogenase (IDH) (2)
  16. IDO (3)
  17. Retinoid Receptor (1)
  18. Lipase (1)
  19. Phospholipases (2)
  20. Lipoxygenase (1)
  21. NAMPT (1)
  22. Antimetabolite (1)
  23. Neuronal Metabolism (1)
  24. DGAT (1)
  25. Vitamin (11)
  26. Decarboxylase (1)
  27. Fatty acid synthase (FASN) (1)
  28. PFKFB3 (1)
  29. Glucosidase (2)
作用机制
  1. Inhibitor (抑制剂) (51)
  2. Agonist (激动剂) (5)
  3. Antagonist (拮抗剂) (2)
  4. Activator (激活剂) (1)
靶点
  1. Carbonic Anhydrase (3)
  2. CETP (1)
  3. HMG-CoA Reductase (4)
  4. KDM1A (LSD1) (1)
  5. MAO-A (1)
  6. MAO-B (1)
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