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Amarogentin
Catalog No. A22286 bitter taste receptor TAS2R1 agonistAmarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. 了解更多 -
Palmitoleic acid
Catalog No. A22291 composition of fatty acidPalmitoleic acid, a composition of fatty acid, is implicated in the prevention of death from cerebrovascular disorders in SHRSP rats. 了解更多 -
3-Hydroxyanthranilic acid
Catalog No. A22292 immunomodulatory agent3-Hydroxyanthranilic Acid (3-HAA, 3-HANA), a tryptophan metabolite, has an immunomodulatory effect that may result from inhibition of PI3K/Akt/mTOR and NF-κB activity, thereby decreasing the production of pro-inflammatory mediators. 了解更多 -
Acetosyringone
Catalog No. A22294 anti-inflammatory agentAcetosyringone is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions. 了解更多 -
Dorzagliatin
Catalog No. A22297 GK activatorDorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes. 了解更多 -
Lavendustin B
Catalog No. A22298 GLUT1 inhibitorLavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 ?M. Lavendustin B is also a weak inhibitor of tyrosine kinases. 了解更多 -
BDTX-189
Catalog No. A22306 Anticancer agentBDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity. 了解更多 -
LDN-193189 2HCl
Catalog No. A22307 BMP signaling inhibitorLDN193189 HCl (DM-3189) is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cell lines, respectively, 200-fold selectivity for BMP versus TGF-β. 了解更多 -
2-Phospho-L-ascorbic acid trisodium
Catalog No. A22309 antioxidant2-Phospho-L-ascorbic acid trisodium acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production. 了解更多 -
L-Quebrachitol
Catalog No. A22312 natural productL-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway. 了解更多 -
Loureirin A
Catalog No. A22313 flavonoidLoureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. 了解更多 -
Alflutinib
Catalog No. A22316 EGFR inhibitorAlflutinib is an EGFR inhibitor that targets both EGFR activating mutations and T790M, thus leading to tumor growth inhibition. 了解更多 -
Mobocertinib
Catalog No. A22334 inhibitor of EGFR and HER2 oncogenic mutantsMobocertinib (TAK-788) is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity. 了解更多 -
Chromium picolinate
Catalog No. A22343 nutritional supplementChromium picolinate is a coordination complex consisting of chromium(III) and picolinic acid. It is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. 了解更多 -
Dihydrocaffeic acid
Catalog No. A22344 Antioxidant agentDihydrocaffeic acid is a phenolic acid found in Gynura bicolor, reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Antioxidant potential and anti-inflammatory activity. 了解更多 -
CCG-222740
Catalog No. A22348 MRTF pathway inhibitorCCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. 了解更多 -
Timosaponin AIII
Catalog No. A22353 Inhibitor of U46619-induced Rat Platelet AggregationTimosaponin AIII is a potent Inhibitor of U46619-induced Rat Platelet Aggregation, Selectively Inhibiting TxA2-induced Platelet Activation, Preferably Suppressing TP-mediated Activation of Gq, not G12/13, Signaling Pathways. 了解更多 -
Beta-asarone
Catalog No. A22354 neuroprotection agentBeta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects. 了解更多 -
Solamargine
Catalog No. A22357 anticancer agentSolamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. 了解更多 -
Remimazolam
Catalog No. A22200 benzodiazepine derivative drugRemimazolam, also known as CNS-7056, is a benzodiazepine derivative drug, developed by PAION, in collaboration with Japanese licensee Ono Pharmaceutical as an alternative to the short-acting imidazobenzodiazepine midazolam, for use in induction of anaesthesia and conscious sedation for minor invasive procedures. 了解更多 -
Etanercept
Catalog No. A12009 TNF inhibitorEtanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. 了解更多 -
Dehydroascorbic acid
Catalog No. A12366 potent cerebroprotectionDehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. 了解更多 -
Periplogenin
Catalog No. A22174 anti-psoriatic agentPeriplogenin is a naturally occurring furanocoumarin found in Angelica dahurica roots, with potent anti-psoriatic effects. Periplogenin induces adipocyte differentiation. 了解更多 -
6-Methoxydihydroavicine
Catalog No. A22177 antiplatelet activities6-Methoxydihydroavicine is an alkaloid isolated from Zanthoxylum integrifoliolum. 6-Methoxydihydroavicine has antiplatelet activities and inhibits AA-, collagen- and PAF-induced platelet aggregation in vitro. 了解更多 -
NSC23005 free acid
Catalog No. A22180 p18INK inhibitorNSC23005 is a p18INK inhibitor. NSC23005 potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). 了解更多 -
Isocyclosporin A
Catalog No. A22205 Isocyclosporin A is a rearranged degradation product formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions. 了解更多 -
Ticlopidine
Catalog No. A22216 inhibitor of platelet aggregationTiclopidine (Yuclid, Ticlopidinum, Ticlopidina) is an orally active inhibitor of platelet aggregation induced by adenosine diphosphate (ADP). 了解更多 -
S29434
Catalog No. A22217 inhibitor of quinone reductase 2 (QR2)S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. 了解更多 -
Almonertinib
Catalog No. A22232 EGFR inhibitorAlmonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. 了解更多 -
Enocitabine
Catalog No. A22234 DNA replication inhibitorEnocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. 了解更多 -
Taletrectinib
Catalog No. A22237 ROS1/NTRK inhibitorTaletrectinib (DS-6051b) is a potent, orally active, and new-generation selective ROS1/NTRK inhibitor. 了解更多 -
Mobocertinib succinate
Catalog No. A22240 EGFR/HER2 oncogenic mutants inhibitorMobocertinib succinate (TAK-788 succinate) is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity. 了解更多 -
ML-335
Catalog No. A22244 OPRM1(μ-opioid receptor)-OPRD1(δ-opioid receptor) heterodimerization agonistML335 (CYM 51010, CID-23723457) is an agonist for OPRM1(μ-opioid receptor)-OPRD1(δ-opioid receptor) heterodimerization with EC50 of 403 nM demonstrating selectivity over the individual OPRM1 and OPRD1 receptors and the serotonin HT5A receptor with EC50 of 14.9 μM, 1.1 μM, and >40 μM, respectively. 了解更多
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