CSF-1R

Catalog No.Inhibitor Name CSF-1ROther
A10025Linifanib
***
VEGFR1/FLT1,FLT3,VEGFR2/KDR
A10679OSI-930
**
FLT1,KDR,LCK
A11959GW2580
*
A13772CEP-32496
***
c-Kit,RET,PDGFRβ
A15520Pexidartinib
**
A15540BLZ945
****
A11472Ki 20227
****
VEGFR-2, PDGFRβ, c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

6 个项目

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  1. AZD7507

    Catalog No. A16886
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    CSF-1R 抑制剂
    AZD7507是一种有效的选择性CSF-1R抑制剂(32 nM细胞活性),AZD7507被认为是一种很有前途的化合物,因为它保留了AZ683所需的效能和口服药代动力学特性。 了解更多
  2. PLX5622

    Catalog No. A18888
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    CSF1R inhibitor
    PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development. 了解更多
  3. JTE-952

    Catalog No. A18391
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    CSF-1R 抑制剂
    TE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. 了解更多
  4. BLZ945

    Catalog No. A15540
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    CSF1R 抑制剂
    BLZ945是有效的选择性CSF-1R激酶抑制剂。它减弱了TAM的周转率,同时增加了浸润宫颈癌和乳腺癌的CD8+ T细胞的数量。 了解更多
  5. Pexidartinib (PLX3397)

    Catalog No. A15520
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    CSF1/Kit/FLT3 抑制剂
    Pexidartinib (PLX3397)是KIT,CSF1R和FLT3的小分子酪氨酸激酶(RTK)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  6. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR 抑制剂
    Pazopanib (GW-786034)是VEGFR-1,VEGFR-2,VEGFR-3,PDGFR-a/β和c-kit的有效且选择性的多靶点酪氨酸激酶抑制剂,可阻止肿瘤生长并抑制血管生成。 了解更多

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