FXR

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  1. GW4064

    Catalog No. A11141
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    FXR 激动剂
    GW4064是选择性的非甾体类法尼醇X受体(FXR)激动剂(EC50 = 15 nM)。 了解更多
  2. WAY-362450

    Catalog No. A11186
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    FXR 激动剂
    WAY-362450是一种高效,选择性和口服可生物利用的法呢类X受体(FXR)激动剂(EC50:4 nM,eff = 149%)。 了解更多
  3. Lithocholic acid

    Catalog No. A12547
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    FXR 激动剂
    Lithocholic acid是胆汁酸,用作去污剂以溶解脂肪以供吸收。 了解更多
  4. T0901317

    Catalog No. A12652
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    LXR/FXR 激动剂
    T0901317是有效的,高亲和力的肝X受体(LXR)激动剂(EC50~50 nM,LXR-β和LXR-β的Kd值分别为7和22 nM)。 了解更多
  5. Obeticholic Acid

    Catalog No. A13866
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    FXR 激动剂
    Obeticholic Acid是一种有效的选择性法呢类X受体(FXR)激动剂,EC50为99 nM。 了解更多
  6. LY2562175

    Catalog No. A17016
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    FXR 激动剂
    LY2562175是体外有效的选择性FXR激动剂,其EC50值为193 nM。具有强大的脂质调节特性,可降低临床前物种中的LDL和甘油三酸酯,同时提高HDL。 了解更多
  7. Px-104

    Catalog No. A16999
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    FXR 激动剂
    Px-104,也称为Px-102,是一种潜在的法呢素X受体(FXR)激动剂,可用于治疗非酒精性脂肪肝。 了解更多
  8. PX20606 trans-isomer

    Catalog No. A16997
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    FXR 激动剂
    PX20606 trans-isomer在小鼠和猴子中诱导高密度脂蛋白介导的跨肝胆固醇外流,并预防胆固醇酯转移蛋白转基因低密度脂蛋白受体(-/-)mice的动脉粥样硬化。 了解更多
  9. Cilofexor

    Catalog No. A13143
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    FXR agonist
    Cilofexor (GS-9674) is a farnesoid X receptor (FXR) agonist. 了解更多
  10. Nidufexor

    Catalog No. A12625
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    FXR agonist
    Nidufexor is a farnesoid X receptor (FXR) agonist. 了解更多
  11. INT-767

    Catalog No. A21494
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    dual FXR/TGR5 agonist
    INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. 了解更多
  12. Fexaramine

    Catalog No. A21771
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    FXR agonist
    Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. 了解更多

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