IAP

Catalog No.Inhibitor Name cIAPXIAPOther
A12738Birinapant
****
**
A14135GDC-0152
***
***
MLXBIR3SG
A13055Embelin
*
5-LO,mPGES-1
A14231BV-6
A11928LCL161
A15800SM-164
****
****
A11163AT406 (SM-406)
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. GDC-0152

    Catalog No. A14135
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    IAP 拮抗剂
    GDC-0152是caspases(Smac)的第二个线粒体激活物,具有潜在的抗肿瘤活性。 了解更多
  2. LCL-161

    Catalog No. A11928
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    拮抗剂of IAPs抑制剂
    LCL161是口服生物可利用的第二个线粒体衍生的半胱天冬酶(SMAC)类似物激活剂,也是IAP(细胞凋亡抑制蛋白)家族蛋白的抑制剂,具有潜在的抗肿瘤活性,抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1 的 IC50分别为 35 和 0.4 nM。 了解更多

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