IAP

Inhibitory Selectivity

Catalog No.	Inhibitor Name	cIAP	XIAP	Other
A12738	Birinapant	****	**
A14135	GDC-0152	***	***	MLXBIR3SG
A13055	Embelin		*	5-LO,mPGES-1
A14231	BV-6
A11928	LCL161
A15800	SM-164	****	****
A11163	AT406 (SM-406)	****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Embelin

Catalog No. A13055
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XIAP 抑制剂

Embelin是一种细胞可渗透的苯醌化合物，具有抗肿瘤特性。了解更多

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Apoptosis Inhibitor (M50054)

Catalog No. A13058
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Apoptosis 抑制剂

Apoptosis Inhibitor (M50054)是细胞可渗透的凋亡诱导抑制剂。了解更多

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AT-406 (SM-406, ARRY-334543)

Catalog No. A11163
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IAP 抑制剂

AT-406 (SM-406,ARRY-334543)是IAP家族蛋白质的口服生物利用抑制剂，具有潜在的凋亡诱导和抗肿瘤活性。AT-406选择性抑制IAP蛋白的生物学活性，包括X染色体连锁IAP（XIAP），细胞IAP 1（c-IAP1）和2（c-IAP2）和黑色素瘤凋亡抑制蛋白（ML-IAP）。了解更多

Product Citations (2)

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- Yoshikawa M, .et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships, J Med Chem, 2018, Mar 22;61(6):2384-2409 PMID: 29485864
- Tsuyoshi Ishii, .et al. CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens, Sci Rep, 2017, 7: 13000 PMID: 29026104
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BV-6

Catalog No. A14231
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dual cIAP and XIAP 抑制剂

BV-6是一种SMAC模拟，双重cIAP和XIAP抑制剂。了解更多

Product Citations (1)

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- Aneri Shah, .et al. YB-1 Mediates TNF-Induced Pro-Survival Signaling by Regulating NF-κB Activation, Cancers (Basel), 2020, Aug 5;12(8):E2188 PMID: 32764479