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| Catalog No. | Inhibitor Name | cIAP | XIAP | Other |
|---|---|---|---|---|
| A12738 | Birinapant | **** | ** | |
| A14135 | GDC-0152 | *** | *** | MLXBIR3SG |
| A13055 | Embelin | * | 5-LO,mPGES-1 | |
| A14231 | BV-6 | |||
| A11928 | LCL161 | |||
| A15800 | SM-164 | **** | **** | |
| A11163 | AT406 (SM-406) | **** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Birinapant (TL32711)
Catalog No. A12738 XIAP/cIAP1 拮抗剂Birinapant (TL32711)是第二个线粒体衍生的胱天蛋白酶（SMAC）激活剂和IAP（凋亡蛋白抑制剂）家族蛋白抑制剂的合成小分子和肽类似物，对cIAP1最有效，无细胞试验中Kd为<1 nM，具有潜在的抗肿瘤活性。 了解更多 -
BV-6
Catalog No. A14231 -
AT-406 (SM-406, ARRY-334543)
Catalog No. A11163 IAP 抑制剂AT-406 (SM-406,ARRY-334543)是IAP家族蛋白质的口服生物利用抑制剂，具有潜在的凋亡诱导和抗肿瘤活性。AT-406选择性抑制IAP蛋白的生物学活性，包括X染色体连锁IAP（XIAP），细胞IAP 1（c-IAP1）和2（c-IAP2）和黑色素瘤凋亡抑制蛋白（ML-IAP）。 了解更多
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