Neuronal Signaling

产品 201 到 250 共 365个

每页
页面:
  1. 3
  2. 4
  3. 5
  4. 6
  5. 7

设置降序顺序
  1. Indiplon

    Catalog No. A13769
    Quick View
    GABAA receptor modulator
    Indiplon是吡唑并嘧啶,可作为GABAA受体的高亲和力正变构调节剂,以剂量依赖和可逆的方式增强GABA活化的氯离子电流。 了解更多
  2. Guvacine hydrochloride

    Catalog No. A13613
    Quick View
    GABA uptake 抑制剂
    Guvacine hydrochloride可抑制GABA的摄取(hGABA T-1,rGABA T-2,hGABA T-3和hBGT-1的IC50值分别为14、58、119和1870 uM)。 了解更多
  3. Muscimol hydrobromide

    Catalog No. A13459
    Quick View
    GABA(A) receptor 激动剂
    Muscimol hydrobromide是抗抑郁药氟西汀的活性代谢产物,可抑制5-羟色胺的摄取,pKi值为7.35.1。诺氟西汀的S-对映体的5-羟色胺再摄取阻断效能比R-对映体高20倍(分别为pKis = 7.86与6.51)。 了解更多
  4. 4-Aminobutyric acid

    Catalog No. A14934
    Quick View
    4-Aminobutyric acid是哺乳动物中枢神经系统的主要抑制性神经递质。 了解更多
  5. Etifoxine

    Catalog No. A15083
    Quick View
    Anxiolytic anticonvulsant
    Etifoxine是培养的神经元中GABAA受体功能的增强剂。 了解更多
  6. Etifoxine hydrochloride

    Catalog No. A15084
    Quick View
    Anxiolytic anticonvulsant
    Etifoxine hydrochloride是培养的神经元中GABAA受体功能的增强剂。 了解更多
  7. Tiagabine

    Catalog No. A13198
    Quick View
    GABA reuptake 抑制剂
    Tiagabine是一种选择性γ-氨基丁酸(gaba)再摄取抑制剂。 了解更多
  8. Picrotoxin

    Catalog No. A14004
    GABAA receptor 拮抗剂
    Picrotoxin是GABAA受体拮抗剂。该化合物已显示可增加下丘脑的去甲肾上腺素水平和周转率。 了解更多
  9. Tiagabine hydrochloride

    Catalog No. A16135
    Quick View
    GABA reuptake 抑制剂
    Tiagabine hydrochloride是一种抗惊厥药。该药物还用于治疗惊恐症,还有其他一些抗惊厥药。 了解更多
  10. Piperazine

    Catalog No. A16171
    Quick View
    GABA receptor 激动剂
    Piperazine是由六元环组成的有机化合物,该六元环在环的相对位置包含两个氮原子。 了解更多
  11. Lorediplon

    Catalog No. A13449
    Quick View
    GABAA receptor modulator
    Lorediplon 是一种新型的非苯二氮卓类催眠药,作为GABAA受体调节剂。 了解更多
  12. U-93631

    Catalog No. A16336
    Quick View
    GABAA receptor ligand
    U-93631是具有新颖化学结构的GABAA受体配体,IC50为100 nM,并且已显示在重组GABAA受体中诱导GABA诱导的全细胞Cl-电流快速,时间依赖性地衰减。 了解更多
  13. Bemegride

    Catalog No. A12298
    Quick View
    Bemegride是一种中枢神经系统兴奋剂, 及Barbiturate中毒的解毒剂。 了解更多
  14. Bamaluzole

    Catalog No. A17107
    Quick View
    GABA receptor 激动剂
    Bamaluzole是GABA受体激动剂。 了解更多
  15. (-)-Securinine

    Catalog No. A17102
    Quick View
    GABA receptor 拮抗剂
    (-)-Securinine是一种最初从S. suffructicosa分离的生物碱。Securinine是一种特定的GABA受体拮抗剂,已发现在体内具有显着的CNS活性。 了解更多
  16. Cgp 52432

    Catalog No. A17140
    Quick View
    GABA-A receptor 拮抗剂
    Cgp 52432是GABA-A受体拮抗剂。 了解更多
  17. Afloqualone

    Catalog No. A17276
    Quick View
    GABA receptor agonist
    Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site. 了解更多
  18. Homotaurine

    Catalog No. A17944
    Quick View
    GABA receptor agonist
    Tramiprosate, also known as homotaurine, is a gamma-Aminobutyric acid (GABA) receptor agonist and a glycosaminoglycan mimetic used in the treatment of Alzheimer's disease. 了解更多
  19. Baclofen

    Catalog No. A18248
    Quick View
    GABA agonist
    Baclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. 了解更多
  20. CGP 36742

    Catalog No. A18666
    Quick View
    GABAB receptor antagonist
    CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood?Cbrain barrier after peripheral administration, with an IC50 of 32?μM. CGP 36742 is useful in treatment of depression. 了解更多
  21. Vigabatrin

    Catalog No. A15277
    Quick View
    GABA-transaminase 抑制剂
    Vigabatrin是抑制性神经递质β-氨基丁酸(GABA)的结构类似物,它不可逆地抑制GABA转氨酶对GABA的分解代谢。 了解更多
  22. CTP354

    Catalog No. A15939
    Quick View
    GABA(A) modulator
    CTP354是一种新型的氘化亚型选择性GABA(A)调节剂。 了解更多
  23. CP-409092

    Catalog No. A20152
    Quick View
    GABAA receptor partial agonist
    CP-409092 is a partial agonist of GABAA receptor, with anti-anxiety activity. 了解更多
  24. TPA 023

    Catalog No. A20140
    Quick View
    GABAA α2/α3 agonist
    TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM. 了解更多
  25. RWJ-51204

    Catalog No. A12875
    Quick View
    partial agonist of GABA(A) receptor
    RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors. 了解更多
  26. MRK-016

    Catalog No. A12046
    Quick View
    GABAA α5 receptor agonist
    MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS. 了解更多
  27. Gabazine

    Catalog No. A12627
    Quick View
    GABAA receptor antagonist
    Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor. 了解更多
  28. Acamprosate calcium

    Catalog No. A11308
    Quick View
    GABA receptor agonist
    Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. 了解更多
  29. U-101017

    Catalog No. A13357
    Quick View
    Benzodiazepine receptor/GABAA receptor agonist
    U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects. 了解更多
  30. (R)-Baclofen

    Catalog No. A16680
    Quick View
    GABAB receptor agonist
    (R)-Baclofen(STX209) is a selective GABAB receptor agonist. 了解更多
  31. L-655708

    Catalog No. A21181
    Quick View
    GABAA receptor inverse agonist
    L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM). 了解更多
  32. Basmisanil

    Catalog No. A21321
    Quick View
    GABAAα5 modulator
    Basmisanil is a highly selective GABAAα5 negative allosteric modulator. 了解更多
  33. CP-409092 hydrochloride

    Catalog No. A21397
    Quick View
    GABAA receptor partial agonist
    CP-409092 hydrochloride is a partial agonist of GABAA receptor, with anti-anxiety activity. 了解更多
  34. NS11394

    Catalog No. A21425
    Quick View
    GABA(A) receptor modulator
    NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors. 了解更多
  35. SCH 50911

    Catalog No. A21630
    Quick View
    γ-Aminobutyric acid B GABA(B) receptor antagonist
    SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist. 了解更多
  36. Gaboxadol hydrochloride

    Catalog No. A21730
    Quick View
    GABAA receptors agonist
    Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects. 了解更多
  37. THIP

    Catalog No. A21738
    Quick View
    δ-GABAAR agonist
    THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist. 了解更多
  38. Jaceosidin

    Catalog No. A12080
    Quick View
    Jaceosidin是一种来源于艾蒿的药理活性黄酮,通过阻断培养的人乳腺上皮细胞中erk-1和-2的磷酸化来抑制佛波酯诱导的cox-2和MMP-9的上调。 了解更多
  39. Fenbufen

    Catalog No. A16002
    Quick View
    Fenbufen是一种具有消炎,镇痛和解热活性的口服活性苯基链烷酸衍生物。 了解更多
  40. Diflunisal

    Catalog No. A16166
    Quick View
    COX 抑制剂
    Diflunisal是具有止痛和抗炎活性的水杨酸衍生物。 了解更多
  41. Amfenac Sodium Monohydrate

    Catalog No. A16399
    Quick View
    COX 抑制剂
    Amfenac Sodium Monohydrate是一种非甾体止痛消炎药,带有乙酸部分。COX1和COX2的IC50值分别为250 nM和150 nM。 了解更多
  42. Ampiroxicam

    Catalog No. A16409
    Quick View
    COX 抑制剂
    Ampiroxicam是一种非选择性的环氧合酶抑制剂,被用作抗炎药。 了解更多
  43. Carprofen

    Catalog No. A16428
    Quick View
    COX-2 抑制剂
    Carprofen通过抑制COX-2和其他炎症性前列腺素来减轻炎症,不干扰COX-1活性。 了解更多
  44. Timegadine

    Catalog No. A17108
    Quick View
    COX and lipo-oxygenase 抑制剂
    Timegadine被发现是一种有效的竞争性环加氧酶(COX)和脂加氧酶抑制剂,IC50的范围从5 nM(洗兔血小板)到20μM(大鼠脑)。在马血小板匀浆的细胞溶质级分和洗涤过的兔血小板中,脂氧化酶的浓度为100μM和100μM。 了解更多
  45. Ketorolac

    Catalog No. A17248
    Quick View
    COX 抑制剂
    Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. 了解更多
    • 最新产品

    Firocoxib

    Catalog No. A17245
    Quick View
    COX-2 抑制剂
    Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses. 了解更多
  46. Aceclofenac

    Catalog No. A17433
    Quick View
    COX-2 抑制剂
    Aceclofenac is a cyclooxygenase-2 inhibitor used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. 了解更多
  47. Naproxen

    Catalog No. A17550
    Quick View
    COX 抑制剂
    Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. 了解更多
  48. Imrecoxib

    Catalog No. A18027
    Quick View
    COX-2 抑制剂
    Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect. 了解更多
  49. Deracoxib

    Catalog No. A18077
    Quick View
    NSAID and COX-2 抑制剂
    Deracoxib is an NSAID and COX-2 inhibitor used to treat osteoarthritis. It induces cell cycle arrest and apoptosis in mammary tumor cells, decreases platelet aggregation, and lowers inflammatory responses. 了解更多

产品 201 到 250 共 365个

每页
页面:
  1. 3
  2. 4
  3. 5
  4. 6
  5. 7

设置降序顺序
Rewards