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PI3K / Akt / mTOR

PI3K / Akt / mTOR

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PF-06409577

Catalog No. A16801
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AMPK 激活剂

PF-06409577是口服生物可利用的AMPK激活剂，在TR-FRET试验中，对AMPK α1β1γ1的EC50为7 nM。在膜片钳试验（100 uM）中没有检测到对hERG的抑制作用，也不是人类主要细胞色素P450亚型微粒体活性的抑制剂（IC50>100 uM）。了解更多

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MK-3903

Catalog No. A17063
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AMPK 激活剂

MK-3903是有效的选择性AMPK激活剂（EC50 = 8 nM）。口服给药后，MK-3903在小鼠肝脏中表现出强大的靶标参与性，从而改善了小鼠的脂质代谢和胰岛素敏感性。了解更多

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ETC-1002

Catalog No. A15815
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ACL 抑制剂 and AMPK 激活剂

ETC-1002是一种新颖的，一流的可以降低LDL-C的小分子；肝AMP激活的蛋白激酶（AMPK）的激活剂;对肝ATP-柠檬酸裂解酶也具有有效的抑制活性（IC50 = 29 uM）。了解更多

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YLF-466D

Catalog No. A16284
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AMPK 激活剂

YLF-466D是一种变构AMPK激活剂。了解更多

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MK8722

Catalog No. A13392
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pan-AMPK activator

MK8722 is a potent and systemic pan-AMPK activator. 了解更多

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ZLN024

Catalog No. A21963
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AMPK allosteric activator

ZLN024 is an AMPK allosteric activator. 了解更多

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GSK621

Catalog No. A15896
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AMPK 激活剂

GSK621是有效的选择性AMPK激动剂。了解更多

Product Citations (1)

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- Harvey W. Smith, .et al. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis, Nat Commun, 2019, 10, 2901(2019) PMID: 31263101
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ex229 (compound 991)

Catalog No. A16795
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AMPK 激活剂

ex229 (compound 991)是一种有效的AMPK活化剂，在活化AMPK方面比A769662的效力高5-10倍。了解更多

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- CN Koyani, .et al. Empagliflozin Protects Heart From Inflammation and Energy Depletion via AMPK Activation, Pharmacol Res, 2020, May 17;158:104870 PMID: 32434052
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Acadesine (Aicar,NSC 105823)

Catalog No. A10028
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AMPK 激活剂

Acadesine (Aicar,NSC 105823)是肝细胞和脂肪细胞中AMPK的选择性激活剂。了解更多

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- R. Lim, .et al. Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators., Placenta, 2015, Apr;36(4):454-62 PMID: 25659498
- Stella Liong, .et al. Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women., J Physiol Biochem, 2015, Dec;71(4):703-17 PMID: 26407807
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A-769662

Catalog No. A11071
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AMPK 激活剂

A-769662是AMP激活的蛋白激酶（AMPK）的新激活剂。了解更多

Product Citations (4)

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- Daniel Missailidis, .et al. Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts, Int J Mol Sci., 2021, Feb; 22(4): 2046 PMID: 33669532
- Lieberthal W, .et al. AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo, Am J Physiol Renal Physiol, 2019, 2019 PMID: 30995114
- Kikuchi H, .et al. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease, Kidney Int, 2018, Nov 13. pii: S0085-2538(18)30635-5 PMID: 30455054
- Schneider H, .et al. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle, Hypertension, 2015, Jul;66(1):108-16 PMID: 26034200
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PS 48

Catalog No. A13484
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PDK1 抑制剂

PS 48是一种变构磷酸肌醇依赖性蛋白激酶-1（PDK1）激活剂（Kd = 10.3μM）。了解更多

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TEPP-46

Catalog No. A16279
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PKM2 activator

TEPP-46是重组丙酮酸激酶M2（PKM2）的有效选择性活化剂，最大活化浓度（AC50值）的一半为92 nM，相对于PKM1，PKL和PKR几乎没有或没有活性。了解更多

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YS-49

Catalog No. A21198
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PI3K/Akt activator

YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. 了解更多

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SC79

Catalog No. A15541
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Akt phosphorylation activator

SC79是AKT激活剂。SC79绑定到模仿PtdIns（3,4,5）P3的结合的Akt的plecktrin同源（PH）域，以诱导Akt的构象变化，从而增强磷酸化和激活。了解更多

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