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使用 'XIAP' 作为标签的产品

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AT-406 (SM-406, ARRY-334543)

Catalog No. A11163
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IAP 抑制剂

AT-406 (SM-406,ARRY-334543)是IAP家族蛋白质的口服生物利用抑制剂，具有潜在的凋亡诱导和抗肿瘤活性。AT-406选择性抑制IAP蛋白的生物学活性，包括X染色体连锁IAP（XIAP），细胞IAP 1（c-IAP1）和2（c-IAP2）和黑色素瘤凋亡抑制蛋白（ML-IAP）。了解更多

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- Yoshikawa M, .et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships, J Med Chem, 2018, Mar 22;61(6):2384-2409 PMID: 29485864
- Tsuyoshi Ishii, .et al. CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens, Sci Rep, 2017, 7: 13000 PMID: 29026104
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Birinapant (TL32711)

Catalog No. A12738
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XIAP/cIAP1 拮抗剂

Birinapant (TL32711)是第二个线粒体衍生的胱天蛋白酶（SMAC）激活剂和IAP（凋亡蛋白抑制剂）家族蛋白抑制剂的合成小分子和肽类似物，对cIAP1最有效，无细胞试验中Kd为<1 nM，具有潜在的抗肿瘤活性。了解更多

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BV-6

Catalog No. A14231
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dual cIAP and XIAP 抑制剂

BV-6是一种SMAC模拟，双重cIAP和XIAP抑制剂。了解更多

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- Aneri Shah, .et al. YB-1 Mediates TNF-Induced Pro-Survival Signaling by Regulating NF-κB Activation, Cancers (Basel), 2020, Aug 5;12(8):E2188 PMID: 32764479
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GDC-0152

Catalog No. A14135
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IAP 拮抗剂

GDC-0152是caspases（Smac）的第二个线粒体激活物，具有潜在的抗肿瘤活性。了解更多

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LCL-161

Catalog No. A11928
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拮抗剂of IAPs抑制剂

LCL161是口服生物可利用的第二个线粒体衍生的半胱天冬酶（SMAC）类似物激活剂，也是IAP（细胞凋亡抑制蛋白）家族蛋白的抑制剂，具有潜在的抗肿瘤活性，抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1 的 IC50分别为 35 和 0.4 nM。了解更多

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- Han-Hee Park, .et al. RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment, Mol Cancer, 2021, Aug 21;20(1):107 PMID: 34419074
- Se-Yeon Park, .et al. Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death, Cell Death & Disease, 2020, 11:744 PMID: 32917855
- J Chen, .et al. Interferon-γ induces the cell surface exposure of phosphatidylserine by activating MLKL in the absence of caspase-8 activity, JBC, 2019, June PMID: 31217278
- Choi SW, .et al. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation, Mol Cell, 2018, Jun 7;70(5):920-935.e7 PMID: 29883609
- Han-Hee Park, .et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis, Exp Mol Med, 2018, Sep; 50(9): 125 PMID: 30237400
- Gi-Bang Koo, .et al. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics, Cell Res, 2015, Jun; 25(6): 707-725 PMID: 25952668
- Kim SK, .et al. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis, J Invest Dermatol, 2015, Aug;135(8):2021-2030 PMID: 25748555
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SM-164

Catalog No. A15800
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cIAP-2 拮抗剂

SM-164是一种有效的细胞渗透性二价Smac模拟物，它与KiAP为0.56 nM的XIAP蛋白结合，并分别与Ki值为0.31和1.1 nM的cIAP-1和cIAP-2蛋白结合。了解更多

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- Hanna Yuk, .et al. Necrostatin-1 Prevents Ferroptosis in a RIPK1- and IDO-Independent Manner in Hepatocellular Carcinoma, Antioxidants (Basel), 2021, Aug 25;10(9):1347 PMID: 34572979
- Caroline Moerke, .et al. The anticonvulsive Phenhydan® suppresses extrinsic cell death, Cell Death Differ, 2018, Nov 15 PMID: 30442947

Adooq Bioscience

使用 'XIAP' 作为标签的产品

AT-406 (SM-406, ARRY-334543)

Birinapant (TL32711)

BV-6

GDC-0152

LCL-161

SM-164

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