Birinapant (TL32711)

目录号: A12738

XIAP/cIAP1 拮抗剂

Birinapant (TL32711)

Birinapant (TL32711) Chemical Structure

CAS NO. 1260251-31-7

Birinapant (TL32711)是第二个线粒体衍生的胱天蛋白酶(SMAC)激活剂和IAP(凋亡蛋白抑制剂)家族蛋白抑制剂的合成小分子和肽类似物,对cIAP1最有效,无细胞试验中Kd为<1 nM,具有潜在的抗肿瘤活性。

库存: 现货

规格 价格 数量
5 mg
¥ 490.00
10 mg
¥ 840.00
25 mg
¥ 1,400.00
50 mg
¥ 1,960.00
10mM * 1mL in DMSO
¥ 700.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Birinapant (TL32711)是第二个线粒体衍生的胱天蛋白酶(SMAC)激活剂和IAP(凋亡蛋白抑制剂)家族蛋白抑制剂的合成小分子和肽类似物,对cIAP1最有效,无细胞试验中Kd为<1 nM,具有潜在的抗肿瘤活性。
靶点信息
cIAP1 (Cell-free assay) XIAP (Cell-free assay)
<1 nM(Kd)45 nM(Kd)
In vitro DMSO 87 mg/mL (107.81 mM)
Water Insoluble
Ethanol 48 mg/mL (59.48 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.39 mL 61.96 mL 123.92 mL
0.5 mM 2.48 mL 12.39 mL 24.78 mL
1 mM 1.24 mL 6.2 mL 12.39 mL
5 mM 0.25 mL 1.24 mL 2.48 mL

*The above data is based on the productmolecular weight 806.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12738
作用机制 Antagonist (拮抗剂)
M. Wt 806.94
Formula C42H56F2N8O6
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1260251-31-7
Synonyms TL-32711, TL 32711
SMILES CC[C@@H](C(=O)N1C[C@H](C[C@H]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[C@@H]6C[C@@H](CN6C(=O)[C@H](CC)NC(=O)[C@H](C)NC)O)O)NC(=O)[C@H](C)NC

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