Vandetanib (ZD6474)

目录号: A10963

VEGFR 抑制剂

Vandetanib (ZD6474)

Vandetanib (ZD6474) Chemical Structure

CAS NO. 443913-73-3

Vandetanib (ZD6474)是一种VEGFR和EGFR拮抗剂,是一种酪氨酸激酶抑制剂,对于HUVEC增殖,PC-9细胞和酪氨酸激酶活性,IC50为60、90、40 nM。

库存: 现货

规格 价格 数量
25 mg
¥ 420.00
50 mg
¥ 700.00
100 mg
¥ 1,400.00
500 mg
¥ 3,150.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Vandetanib (ZD6474)是一种VEGFR和EGFR拮抗剂,是一种酪氨酸激酶抑制剂,对于HUVEC增殖,PC-9细胞和酪氨酸激酶活性,IC50为60、90、40 nM。
靶点信息
VEGFR2 (Cell-free assay)
40 nM
In vitro (25°C) DMSO 4 mg/mL (8.41 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% CMC Na 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.03 mL 105.17 mL 210.35 mL
0.5 mM 4.21 mL 21.03 mL 42.07 mL
1 mM 2.1 mL 10.52 mL 21.03 mL
5 mM 0.42 mL 2.1 mL 4.21 mL

*The above data is based on the productmolecular weight 475.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10963
作用机制 Inhibitor (抑制剂)
M. Wt 475.4
Formula C22H24BrFN4O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 443913-73-3
Synonyms ZD6474
SMILES CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC

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