PLX7904

目录号: A15855

Raf 抑制剂

PLX7904

PLX7904 Chemical Structure

CAS NO. 1393465-84-3

PLX7904是有效的选择性悖论突破性RAF抑制剂。它能够有效抑制突变型BRAF黑色素瘤细胞中ERK1/2的激活,但不能过度激活突变型RAS表达细胞中的ERK1/2。

库存: 现货

规格 价格 数量
5 mg
¥ 385.00
10 mg
¥ 630.00
25 mg
¥ 1,260.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

PLX7904是有效的选择性悖论突破性RAF抑制剂。它能够有效抑制突变型BRAF黑色素瘤细胞中ERK1/2的激活,但不能过度激活突变型RAS表达细胞中的ERK1/2。
靶点信息
Raf
In vitro DMSO 87 mg/mL (169.75 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.51 mL 97.56 mL 195.11 mL
0.5 mM 3.9 mL 19.51 mL 39.02 mL
1 mM 1.95 mL 9.76 mL 19.51 mL
5 mM 0.39 mL 1.95 mL 3.9 mL

*The above data is based on the productmolecular weight 512.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A15855
作用机制 Inhibitor (抑制剂)
M. Wt 512.53
Formula C24H22F2N6O3S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1393465-84-3
Synonyms PB04
SMILES O=C(C1=CNC2=NC=C(C3=CN=C(C4CC4)N=C3)C=C21)C5=C(F)C=CC(NS(=O)(N(CC)C)=O)=C5F

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