BLU9931

目录号: A15534

FGFR 抑制剂

BLU9931

BLU9931 Chemical Structure

CAS NO. 1538604-68-0

BLU9931是第一种选择性的FGFR4小分子抑制剂,IC50为3 nM。对FGFR1/2/3的效力较低(IC50> 150 nM)。

库存: 现货

规格 价格 数量
5 mg
¥ 350.00
10 mg
¥ 595.00
25 mg
¥ 1,050.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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BLU9931是第一种选择性的FGFR4小分子抑制剂,IC50为3 nM。对FGFR1/2/3的效力较低(IC50> 150 nM)。
靶点信息
FGFR4 FGFR3 FGFR2 FGFR1
3 nM150 nM493 nM591 nM
In vitro (25°C) DMSO Warmed: 4 mg/mL (7.85 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% carboxymethylcellulose+1% Tween 80 as a suspension 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.63 mL 98.16 mL 196.32 mL
0.5 mM 3.93 mL 19.63 mL 39.26 mL
1 mM 1.96 mL 9.82 mL 19.63 mL
5 mM 0.39 mL 1.96 mL 3.93 mL

*The above data is based on the productmolecular weight 509.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A15534
作用机制 Inhibitor (抑制剂)
M. Wt 509.38
Formula C26H22Cl2N4O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1538604-68-0
Synonyms BLU-9931, BLU 9931
SMILES CC1=C(C(=CC=C1)NC(=O)C=C)NC2=NC=C3C=C(C=CC3=N2)C4=C(C(=CC(=C4Cl)OC)OC)Cl

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