Refametinib

目录号: A11264

MEK 抑制剂

Refametinib

Refametinib Chemical Structure

CAS NO. 923032-37-5

Refametinib是一种有效的,ATP非竞争性和高度选择性的MEK1和MEK2抑制剂,IC50分别为19 nM和47 nM。

库存: 现货

规格 价格 数量
10 mg
¥ 630.00
25 mg
¥ 1,260.00
50 mg
¥ 2,100.00
10mM * 1mL in DMSO
¥ 777.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Refametinib是一种有效的,ATP非竞争性和高度选择性的MEK1和MEK2抑制剂,IC50分别为19 nM和47 nM。
靶点信息
MEK1 MEK2
19 nM47 nM
In vitro DMSO 95 mg/mL (165.98 mM)
Water Insoluble
Ethanol 95 mg/mL (165.98 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.47 mL 87.36 mL 174.72 mL
0.5 mM 3.49 mL 17.47 mL 34.94 mL
1 mM 1.75 mL 8.74 mL 17.47 mL
5 mM 0.35 mL 1.75 mL 3.49 mL

*The above data is based on the productmolecular weight 572.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11264
作用机制 Inhibitor (抑制剂)
M. Wt 572.34
Formula C19H20F3IN2O5S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 923032-37-5
Synonyms BAY 869766,RDEA119, Bay 86-9766
SMILES COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[C@@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F

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