NVP-BHG712

目录号: A10661

EphB4 抑制剂

NVP-BHG712

NVP-BHG712 Chemical Structure

CAS NO. 940310-85-0

NVP-BHG712是EphB4激酶的选择性抑制剂,在体外对EphB4的选择性超过40多种其他激酶(包括FGFR3)。

库存: 现货

规格 价格 数量
5 mg
¥ 560.00
10 mg
¥ 1,050.00
50 mg
¥ 4,200.00
100 mg
¥ 7,000.00
10mM * 1mL in DMSO
¥ 840.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

NVP-BHG712是EphB4激酶的选择性抑制剂,在体外对EphB4的选择性超过40多种其他激酶(包括FGFR3)。
Targets
Target Value
EphB4ED5025nM
C-RafIC50: 0.395μM
c-SrcIC50: 1.266μM
c-AblIC50: 1.667μM
Tie-2IC50: >10μM
AxlIC50: >10μM
HER1IC50: >10μM
PKAIC50: >10μM
CDK1IC50: >10μM
PKBIC50: >10μM
PDK-1IC50: >10μM
FGFR3IC50: >10μM
c-MetIC50: >10μM
In vitro (25°C) DMSO 90 mg/mL (178.75 mM)
Water Insoluble
Ethanol 3 mg/mL (5.95 mM)
In vivo NMP+PEG300 (10+90, v+v) 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.3 mL 198.61 mL
0.5 mM 3.97 mL 19.86 mL 39.72 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

*The above data is based on the productmolecular weight 503.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10661
作用机制 Inhibitor (抑制剂)
M. Wt 503.5
Formula C26H20F3N7O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 940310-85-0
Synonyms NVPBHG712
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5

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