产品详情
RAF265 (CHIR-265)是一种口服,高度选择性的RAF和VEGFR激酶抑制剂,可控制或正常化VEGFR-2,同时抑制B-raf和c-Raf突变以预防癌症。
靶点信息
VEGFR2 (Cell-free assay) | B-Raf (Cell-free assay) | |||
30 nM(EC50) | 3 nM-60 nM |
In vitro (25°C) | DMSO | 85 mg/mL (163.96 mM) | |
Water | Insoluble | ||
Ethanol | 28 mg/mL (54.01 mM) | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 19.29 mL | 96.45 mL | 192.9 mL |
0.5 mM | 3.86 mL | 19.29 mL | 38.58 mL |
1 mM | 1.93 mL | 9.65 mL | 19.29 mL |
5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
*The above data is based on the productmolecular weight 518.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A10773 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 518.4 |
Formula | C24H16F6N6O |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 927880-90-8 |
SMILES | CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
PLX4032 (Vemurafenib)
PLX4032(Vemurafenib)也称为RG7204,Vemurafenib,R7204,RO5185426。PLX4032是B-raf抑制剂,IC50为44 nM。
NVP-BHG712
NVP-BHG712是EphB4激酶的选择性抑制剂,在体外对EphB4的选择性超过40多种其他激酶(包括FGFR3)。
E7080 (Lenvatinib)
E7080 (Lenvatinib)是一种多激酶抑制剂,可同时抑制VEGFR2和VEGFR3激酶。
Keywords:购买 RAF265 (CHIR-265) | RAF265 (CHIR-265) 供应商 | 订购 RAF265 (CHIR-265) | RAF265 (CHIR-265) 价格 | RAF265 (CHIR-265) 生产商 | 订单 RAF265 (CHIR-265) | RAF265 (CHIR-265) 代理商 | 购买 927880-90-8| 927880-90-8 供应商 | 订购 927880-90-8 | 927880-90-8 价格 | 927880-90-8 生产商 | 订单 927880-90-8 | 927880-90-8 代理商|buy RAF265 (CHIR-265) | RAF265 (CHIR-265) Supplier | purchase RAF265 (CHIR-265) | RAF265 (CHIR-265) cost | RAF265 (CHIR-265) manufacturer | order RAF265 (CHIR-265) | RAF265 (CHIR-265) distributor | buy 927880-90-8| 927880-90-8 Supplier | purchase 927880-90-8 | 927880-90-8 cost | 927880-90-8 manufacturer | order 927880-90-8 | 927880-90-8 distributor