RAF265 (CHIR-265)

目录号: A10773

RAF/VEGFR 抑制剂

RAF265 (CHIR-265)

RAF265 (CHIR-265) Chemical Structure

CAS NO. 927880-90-8

RAF265 (CHIR-265)是一种口服,高度选择性的RAF和VEGFR激酶抑制剂,可控制或正常化VEGFR-2,同时抑制B-raf和c-Raf突变以预防癌症。

库存: 现货

规格 价格 数量
5 mg
¥ 665.00
10 mg
¥ 1,134.00
25 mg
¥ 1,995.00
50 mg
¥ 3,325.00
10mM * 1mL in DMSO
¥ 1,281.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

RAF265 (CHIR-265)是一种口服,高度选择性的RAF和VEGFR激酶抑制剂,可控制或正常化VEGFR-2,同时抑制B-raf和c-Raf突变以预防癌症。
靶点信息
VEGFR2 (Cell-free assay) B-Raf (Cell-free assay)
30 nM(EC50)3 nM-60 nM
In vitro (25°C) DMSO 85 mg/mL (163.96 mM)
Water Insoluble
Ethanol 28 mg/mL (54.01 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.29 mL 96.45 mL 192.9 mL
0.5 mM 3.86 mL 19.29 mL 38.58 mL
1 mM 1.93 mL 9.65 mL 19.29 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 518.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10773
作用机制 Inhibitor (抑制剂)
M. Wt 518.4
Formula C24H16F6N6O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 927880-90-8
SMILES CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F

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