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SR9243

Catalog No. A15535
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LXR 激动剂

SR9243是有效的选择性LXR反向激动剂。SR9243通过抑制脂质产生和Warburg效应杀死癌细胞。它在多种类型的癌症中诱导细胞死亡，并且不会引起副作用，而这些副作用已使先前针对这些过程的尝试脱轨。了解更多

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APD668

Catalog No. A14342
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GPR119 激动剂

APD668是有效的GPR119激动剂，hGPR119和ratGPR119的EC50分别为2.7 nM和33 nM。了解更多

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lorcaserin hydrochloride (APD-356)

Catalog No. A12598
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serotonin 2C receptor 激动剂

lorcaserin hydrochloride (APD-356)是血清素2C受体激动剂，可指示与减少热量饮食和增加体育锻炼以减轻慢性体重成人管理。了解更多

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- Li Li, .et al. Delineating a serotonin 1B receptor circuit for appetite suppression in mice, J Exp Med, 2022, Aug 1;219(8):e20212307 PMID: 35796804
- Henrik H. Hansen, .et al. Whole-brain activation signatures of weight-lowering drugs, Mol Metab, 2021, May;47:101171 PMID: 33529728
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WIN 55,212-2 mesylate

Catalog No. A11932
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CB receptor 激动剂

WIN 55,212-2 mesylate是一种有效的cannabinoid receptor激动剂，在神经性疼痛的大鼠模型中具有有效的镇痛作用。它通过受体介导的信号激活p42和p44 MAP激酶。了解更多

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- Greish K, .et al. Synthetic cannabinoids nano-micelles for the management of triple negative breast cancer, J Control Release, 2018, Dec 10;291:184-195 PMID: 30367922
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PNU 282987

Catalog No. A11233
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α7 nAChR 激动剂

PNU 282987 (PNU-282,987)可作为神经烟碱乙酰胆碱受体α7亚型的有效选择性激动剂。了解更多

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GW4064

Catalog No. A11141
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FXR 激动剂

GW4064是选择性的非甾体类法尼醇X受体（FXR）激动剂（EC50 = 15 nM）。了解更多

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- Dong-Hyun Kim, .et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD, Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
- Takae K, .et al. Evidence for the involvement of FXR signaling in ovarian granulosa cell function, J Reprod Dev, 2018, Nov 16 PMID: 30449821
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Synephrine (Oxedrine)

Catalog No. A10882
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Adrenergic Receptor 激动剂

Synephrine (Oxedrine)是一种通常用于减肥的胺化合物。了解更多

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Nalmefene hydrochloride

Catalog No. A13843
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dopamine receptor 激动剂

Nalmefene hydrochloride是opioid receptor拮抗剂。了解更多

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- Mark G Papich, .et al. Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection, Drug Deliv Transl Res, 2022, Feb;12(2):376-383 PMID: 34817831
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NMDA

Catalog No. A12751
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NMDA receptor 激动剂

NMDA是一种原型NMDA受体激动剂。了解更多

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Carvedilol

Catalog No. A11843
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β2-adrenergic receptor

Carvedilol是具有抗氧化特性的β1和β2肾上腺素能受体（AR）激动剂。了解更多

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Aripiprazole (Abilify)

Catalog No. A11801
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5-HT1A receptor 激动剂

Aripiprazole (Abilify)是人5-HT1A受体部分激动剂，Ki为4.2 nM。了解更多

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- Jaime Osuna-Luque, .et al. Behavioral Mechanisms That Depend on Dopamine and Serotonin in Caenorhabditis elegans Interact With the Antipsychotics Risperidone and Aripiprazole, J Exp Neurosci, 2018, 12: 1179069518798628 PMID: 30245571
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pirinixic acid (WY 14643)

Catalog No. A12360
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PPARα 激动剂

pirinixic acid (WY 14643)是一种高效pparα激动剂。了解更多

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Imiquimod (Aldara)

Catalog No. A10469
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TLR7 激动剂

Imiquimod (Aldara)是一种杂环咪唑并喹啉酰胺，用作免疫反应调节剂。了解更多

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- David Diaz-Carballo, .et al. Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors, Commun Biol, 2021, Mar 3;4(1):276 PMID: 33658617
- Kunishita Y, .et al. TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis, Front Immunol, 2020, Feb 7;11:98 PMID: 32117252