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(S)-10-Hydroxycamptothecin

Catalog No. A11997
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Topoisomerase

(S)-10-Hydroxycamptothecin是喜树碱衍生物，它通过在染色体DNA中产生链断裂并诱导细胞凋亡来抑制DNA拓扑异构酶。了解更多

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SN 38

Catalog No. A12011
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DNA topoisomerase 抑制剂

SN 38是依立替康(喜树碱的类似物-拓扑异构酶I抑制剂)的活性代谢物。了解更多

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- Chen JC, .et al. In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells, Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
- Alibolandi M, .et al. Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38, Artif Cells Nanomed Biotechnol, 2018, May 27:1-12 PMID: 29806500
- Bar-Zeev M, .et al. β-Casein micelles for oral delivery of SN-38 and elacridar to overcome BCRP-mediated multidrug resistance in gastric cancer, Eur J Pharm Biopharm, 2018, Dec;133:240-249 PMID: 30367935
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Topotecan HCl (Hycamtin)

Catalog No. A10939
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DNA topoisomerase I 抑制剂

Topotecan HCl (Hycamtin)是一种化学治疗剂，是拓扑异构酶抑制剂。了解更多

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Doxorubicin

Catalog No. A14403
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Topoisomerase II 抑制剂

Doxorubicin是一种抑制DNA拓扑异构酶II并诱导DNA损伤和凋亡的抗生素。了解更多

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- J Priyanga, .et al. A novel indenone derivative selectively induces senescence in MDA-MB-231 (breast adenocarcinoma) cells, Chem Biol Interact, 2020, Nov 1;331:109250 PMID: 32956706
- Abdelrehim A, .et al. The use of tail-anchored protein chimeras to enhance liposomal cargo delivery, PLoS One, 2019, Feb 22;14(2):e0212701 PMID: 30794671
- J Wei, .et al. Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling, bioRxiv, 2018, 2018
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BNS-22

Catalog No. A13443
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Topo II 抑制剂

BNS-22是Topo II的有效小分子抑制剂（Topo II alpha和Topo II beta的IC50分别为2.8 M和0.42 M）。了解更多

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SW044248

Catalog No. A15837
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TOP1 抑制剂?

SW044248是一种新型的非规范性Top1抑制剂，对NSCLC细胞具有选择性毒性。了解更多

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Daun02

Catalog No. A21818
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prodrug of the topoisomerase inhibitor Daunorubicin

Daun02 is a prodrug of the topoisomerase inhibitor Daunorubicin. 了解更多

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