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搜索结果：“gdc 0084”

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GDC-0349

Catalog No. A11443
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mTOR 抑制剂

GDC-0349是一种有效的，选择性的，ATP竞争性的mTOR抑制剂，Ki为3.8 nM，比作用于PI3Kα和其他266种激酶的抑制效果高790倍。了解更多

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GDC-0879

Catalog No. A10420
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B-Raf 抑制剂

GDC-0879是B-Raf激酶的特异性抑制剂，靶向B-Raf (V600E) (IC50: 0.13 nM)。了解更多

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GDC-0980 (Apitolisib, RG7422)

Catalog No. A11023
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mTOR/PI3K 抑制剂

GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。了解更多

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- Kasun Wanigasooriya, .et al. Patient Derived Organoids Confirm That PI3K/AKT Signalling Is an Escape Pathway for Radioresistance and a Target for Therapy in Rectal Cancer, Front Oncol, 2022, Jul 4;12:920444 PMID: 35860583
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GDC-0941 (Pictilisib)

Catalog No. A10421
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PI3K 抑制剂

GDC-0941 (Pictilisib)是一种强效、选择性、口服生物可利用的I类PI3激酶(PI3K)抑制剂，p110 α、β、δ和γ亚型、DNA-PK和mTOR的IC50值分别为3、33、3、75、1230和580 nM。了解更多

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- Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
- Joo Sang Lee, .et al. Harnessing synthetic lethality to predict the response to cancer treatment, Nat Commun, 2018, 9: 2546 PMID: 29959327
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GDC-0068 (Ipatasertib, RG-7440)

Catalog No. A11246
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Akt 抑制剂

GDC-0068 (Ipatasertib,RG-7440)是一种选择性的，具有ATP竞争性的pan-Akt抑制剂，在无细胞试验中，其靶向Akt1、2和3的IC50值分别为5、18和8 nM。了解更多

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GDC-0449 (Vismodegib)

Catalog No. A10258
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Hedgehog 拮抗剂

GDC-0449 (Vismodegib)是一种新型有效的，特异性hedgehog抑制剂，IC50为3 nM。了解更多

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- Daniel Doheny, .et al. Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis, Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
- Yi Yang, .et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806
- Olesen UH, .et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 PMID: 30152536
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Arbutin (Uva, p-Arbutin)

Catalog No. A10084
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Tyrosinase 抑制剂

Arbutin (Uva,p-Arbutin)是用于中药（TCM）的糖基化对苯二酚。熊果苷由于其酪氨酸酶抑制活性而抑制黑色素的形成。了解更多

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