VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. 了解更多

FzM1.8 is an allosteric agonist of the Frizzled receptor FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K. 了解更多

BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28?μM and Amax ratio?of 98%. 了解更多

Baclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. 了解更多

Trimebutine Maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Trimebutine Maleate modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome. 了解更多

Lusutrombopag, also known as S-888711, is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist being developed by Shionogi for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery. 了解更多

Tramiprosate, also known as homotaurine, is a gamma-Aminobutyric acid (GABA) receptor agonist and a glycosaminoglycan mimetic used in the treatment of Alzheimer's disease. 了解更多

Canrenone is a metabolite of spironolactone, Na/K ATPase partial agonist and aldosterone and androgen receptor antagonist used as a diuretic. 了解更多

MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist. 了解更多

Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site. 了解更多

Bamaluzole是GABA受体激动剂。 了解更多

Rimonabant hydrochloride是CB1受体反向激动剂。 了解更多

AGN 205327是一种有效的合成RARs激动剂，对RARα/β/γ的EC50分别为3766/734/32 nM；对RXR无抑制作用。 了解更多

Piperazine是由六元环组成的有机化合物，该六元环在环的相对位置包含两个氮原子。 了解更多

Muscimol hydrobromide是抗抑郁药氟西汀的活性代谢产物，可抑制5-羟色胺的摄取，pKi值为7.35.1。诺氟西汀的S-对映体的5-羟色胺再摄取阻断效能比R-对映体高20倍（分别为pKis = 7.86与6.51）。 了解更多

Guanabenz acetate是a2A-AR肾上腺素能激动剂和IGRS（咪唑啉I2结合位点）选择性配体。 了解更多

ABT-418 HCl是神经元烟碱型乙酰胆碱受体激动剂。 了解更多

Sofinicline (ABT-894,A-422894)是一种新型的烟碱型乙酰胆碱受体激动剂，可治疗注意力不足/多动症。 了解更多

a5IA是促智药物，它在GABAA受体的苯并二氮杂卓结合位点上起亚型选择性反向激动剂的作用。 了解更多

Tedalinab (GRC-10693)是开发用于治疗骨关节炎和神经性疼痛的药物，它可作为有效的选择性大麻素CB2受体激动剂。与相关的CB1受体相比，它对CB2的选择性为4700x，具有很高的口服生物利用度，并在早期临床试验中显示出令人鼓舞的安全性结果以及有效的镇痛和抗炎作用。 了解更多

Bretazenil，苯二氮卓类受体局部激动剂，可预防OP中毒。 了解更多

Cabergoline是一种有效的多巴胺D2受体激动剂。 了解更多

AWD 131-138是一种新的低亲和力的部分苯二氮卓类受体激动剂，在啮齿动物模型中具有强大的抗惊厥和抗焦虑特性。 了解更多

Aripiprazole (Abilify)是人5-HT1A受体部分激动剂，Ki为4.2 nM。 了解更多

WIN 55,212-2 mesylate是一种有效的cannabinoid receptor激动剂，在神经性疼痛的大鼠模型中具有有效的镇痛作用。它通过受体介导的信号激活p42和p44 MAP激酶。 了解更多