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PD-1-IN-18
Catalog No. A12148 PD1 signaling pathway inhibitorPD-1-IN-18 is a PD1 signaling pathway inhibitor, which acts as an immunomodulator. 了解更多 -
Enzaplatovir
Catalog No. A20830 RSV fusion protein inhibitorEnzaplatovir is an inhibitor of Respiratory Syncytial Virus (RSV). It can be used as a viral fusion protein inhibitor. 了解更多 -
TRPC6-IN-1
Catalog No. A12309 TRPC6 inhibitorTRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM. 了解更多 -
c-Fms-IN-9
Catalog No. A18397 c-FMS inhibitorc-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1, Compound Example 7. c-Fms-IN-9 inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT with IC50s of <0.01 μM and 0.1-1 μM, respectively. 了解更多 -
MAC glucuronide phenol-linked SN-38
Catalog No. A18403 DNA topoisomerase I inhibitorMAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) drug linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively. 了解更多 -
MAC glucuronide α-hydroxy lactone-linked SN-38
Catalog No. A18407 Topoisomerase I inhibitorMAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. 了解更多 -
Abemaciclib Metabolites M2
Catalog No. A18416 CDK4/CDK6 inhibitorAbemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity. 了解更多 -
IDH1 Inhibitor 2
Catalog No. A18420 IDH1 inhibitorDH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM. 了解更多 -
DRAK2-IN-1
Catalog No. A18433 DRAK2 inhibitorDRAK2-IN-1, compound 16, is a potent, selective and ATP-competitive DRAK2 inhibitor with IC50and Kivalues of 3 nM and 0.26 nM, respectively. DRAK2-IN-1 also has inbitory effect on DRAK1 (IC50=51 nM). 了解更多 -
PD-1-IN-22
Catalog No. A18434 PD-1/PD-L1 interaction inhibitorPD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM. 了解更多 -
c-Kit-IN-2
Catalog No. A18440 c-KIT inhibitorc-Kit-IN-2 is a c-KIT inhibitor with an IC50 of 82 nM, shows superior antiproliferative activities against all the three GIST cell lines, GIST882, GIST430, and GIST48, with GI50s of 3, 1, and 2 nM, respectively. 了解更多 -
KRAS G12C inhibitor 17
Catalog No. A18441 KRAS G12C inhibitorKRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM. 了解更多 -
KRAS G12C inhibitor 16
Catalog No. A18444 KRAS G12C inhibitorKRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 39, has an IC50 of 97 nM. 了解更多 -
KRAS G12C inhibitor 15
Catalog No. A18447 KRAS G12C inhibitorKRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM. 了解更多 -
MD2-TLR4-IN-1
Catalog No. A18452 MD2-TLR4 inhibitorMD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. 了解更多 -
CHMFL-KIT-033
Catalog No. A18476 c-KIT T670I mutant inhibitorCHMFL-KIT-033 is a potent and selective inhibitor of c-KIT T670I mutant for gastrointestinal stromal tumors (GISTs), with an IC50 of 0.045 μM. 了解更多 -
MC-Val-Cit-PAB-clindamycin
Catalog No. A18487 protein synthesis inhibitorMC-Val-Cit-PAB-clindamycin is a drug-linker conjugate for ADC with potent antitumor activity by using clindamycin (a protein synthesis inhibitor), linked via the ADC linker MC-Val-Cit-PAB. 了解更多 -
MC-Sq-Cit-PAB-Dolastatin10
Catalog No. A18518 tubulin polymerization inhibitorMC-Sq-Cit-PAB-Dolastatin10 is a drug-linker conjugate for ADC with potent antitumor activity by using Dolastatin10 (a tubulin polymerization inhibitor), linked via the ADC linker MC-Sq-Cit-PAB. 了解更多 -
Mutated EGFR-IN-2
Catalog No. A18565 EGFR 抑制剂Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=??1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity. 了解更多 -
PARP14 inhibitor H10
Catalog No. A18616 PARP14 抑制剂PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (??24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis. 了解更多 -
Dynarrestin
Catalog No. A18662 dyneins 1/2 inhibitorDynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. 了解更多 -
Glutaminase-IN-1
Catalog No. A18668 KGA inhibitorGlutaminase-IN-1 (CB839 derivative), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. 了解更多 -
BRD4 Inhibitor-10
Catalog No. A18679 BRD4-BD1 inhibitorBRD4 Inhibitor-10 is a potent BRD4-BD1 inhibitor extracted from patent WO2015022332A1, Compound II-25, has an IC50 of 8 nM. 了解更多 -
BuChE-IN-TM-10
Catalog No. A18693 BuChE inhibitorBuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. 了解更多 -
MARK4 inhibitor 1
Catalog No. A18695 (MARK4 inhibitorMARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. 了解更多 -
para-Nitroblebbistatin
Catalog No. A18718 Myosin II inhibitorpara-Nitroblebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies. 了解更多 -
URAT1 inhibitor 1
Catalog No. A18720 URAT1 inhibitorURAT1 inhibitor 1 (1g) is a uric acid transporter 1 (URAT1) inhibitor, with an IC50 of 32 nM. URAT1 inhibitor 1 has potential to treat hyperuricemia associated with gout. 了解更多 -
Rodatristat
Catalog No. A18820 TPH1/TPH2 inhibitorRodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice. 了解更多 -
KRAS G12C inhibitor 5
Catalog No. A18840 KRas G12C inhibitorKRAS G12C inhibitor 5 is a KRas G12C inhibitor extracted from patent WO2017201161A1, Compound example 147. 了解更多 -
Bromodomain IN-1
Catalog No. A18845 Bromodomain inhibitorBromodomain IN-1 is a Bromodomain inhibitor extracted from patent WO2016069578A1, compound 4 . 了解更多 -
LYPLAL1-IN-1
Catalog No. A18852 LYPLAL1 inhibitorLYPLAL1-IN-1 (Compound 11) is an selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (LYPLAL1) with an IC50 of 0.006 μM. LYPLAL1-IN-1 increases glucose production. 了解更多 -
MMSET-IN-1
Catalog No. A18860 SET domain inhibitorMMSET-IN-1 is a multiple myeloma SET domain (MMSET, aka NSD2/WHSC1) inhibitor against SETD2 and MMSET with IC50s of 0.49 and 3.3 μM, respectively. MMSET-IN-1 has a Kd of 1.6 μM for MMSET. 了解更多 -
Complement C5-IN-1
Catalog No. A18864 C5 inhibitorComplement C5-IN-1 (Compound 7) is a small-molecule inhibitor of complement component 5 protein (C5). 了解更多 -
PROTAC MDM2 Degrader-4
Catalog No. A18877 MDM2 inhibitorPROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多 -
c-Fms-IN-8
Catalog No. A18879 CSF-1R, c-FMS Type II inhibitorc-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. 了解更多 -
PROTAC MDM2 Degrader-2
Catalog No. A18890 MDM2 inhibitorPROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多 -
Tuberculosis inhibitor 1
Catalog No. A18906 trypanosoma brucei growth inhibitorTuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC50 of 5 nM. 了解更多 -
JAK3 covalent inhibitor-1
Catalog No. A18926 JAK3 covalent 抑制剂JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs. 了解更多
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