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Solabegron
Catalog No. A20778 β3-adrenergic receptor agonistSolabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM. 了解更多 -
WAY-204688
Catalog No. A20757 NF-κB inhibitorWAY-204688 is an estrogen receptor (ER-α) selective, orally active inhibitor of NF-κB transcriptional activity with an IC50 of 122?±?30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells. 了解更多 -
NSC23005 sodium
Catalog No. A20665 p18 inhibitorNSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. 了解更多 -
JNJ-18038683
Catalog No. A20659 5-HT7 receptor antagonistJNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively. 了解更多 -
Saroglitazar
Catalog No. A20636 PPAR agonistSaroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. 了解更多 -
3-Bromopyruvic acid
Catalog No. A20605 hexokinase II inhibitor3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells. 了解更多 -
NI-42
Catalog No. A20599 BRD inhibitorNI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins. 了解更多 -
Ecteinascidin 770
Catalog No. A20525 Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM. 了解更多 -
Tefinostat
Catalog No. A20258 pan HDAC inhibitorTefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity. 了解更多 -
Recilisib (free acid)
Catalog No. A20255 radioprotectantRecilisib is a radioprotectant, which can activate AKT, PI3K activities in cells. 了解更多 -
JH-VIII-157-02
Catalog No. A20205 ALK inhibitorJH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. 了解更多 -
DC1SMe
Catalog No. A20181 DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. 了解更多 -
STAT5-IN-2
Catalog No. A20126 STAT5 inhibitorSTAT5-IN-2 is a STAT5 inhibitor with EC50s of 9 μM and 5 μM in K562 and KU812 cells, respectively. Potent antileukemic effect. 了解更多 -
5α-Pregnane-3β,6α-diol-20-one
Catalog No. A20118 5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells. 了解更多 -
IL-15-IN-1
Catalog No. A20113 IL-15 inhibitorIL-15-IN-1 is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM. 了解更多 -
mTOR inhibitor-1
Catalog No. A20029 mTOR inhibitormTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. 了解更多 -
BRD4 degrader AT1
Catalog No. A19956 Brd4 degraderBRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells. 了解更多 -
S-methyl-KE-298
Catalog No. A19954 S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. 了解更多 -
ML 145
Catalog No. A19953 GPR35/CXCR8 antagonistML 145 is a selective GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM, but not for the related GPR55 orphan receptor. GPR35 is expressed by various cells of the immune system and it may has potential as a therapeutic target in inflammatory disease. 了解更多 -
Leelamine hydrochloride
Catalog No. A19910 CB1 agonistLeelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. 了解更多 -
EPAC 5376753
Catalog No. A19890 Epac inhibitorEPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 ?M in Swiss 3T3 cells. 了解更多 -
GR 159897
Catalog No. A19862 NK2 antagonistGR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide antagonist at tachykinin NK2 receptors, inhibits binding of [3H]GR100679 to hNK2-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction, with anxiolytic-like activity. 了解更多 -
ATRA-hydroxyimino
Catalog No. A19791 ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells. 了解更多 -
PROTAC CRABP-II Degrader-1
Catalog No. A19782 CRABP-II degraderPROTAC CRABP-II Degrader-1 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1. 了解更多
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