Epigenetics

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  1. CUDC-907 (Fimepinostat)

    Catalog No. A11153
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    PI3K/HDAC 抑制剂
    CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂,作用于PI3Kα和HDAC1/2/3/10,IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。 了解更多
  2. KD 5170

    Catalog No. A15354
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    HDAC 抑制剂
    KD 5170是一种新型的基于巯基酮的组蛋白脱乙酰基酶抑制剂,在体外和体内均表现出广谱的抗肿瘤活性。 了解更多
  3. HDAC-IN-7

    Catalog No. A21252
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    HDAC1/2/3/10 inhibitor
    HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. 了解更多
  4. CI994 (Tacedinaline)

    Catalog No. A11964
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    HDAC 抑制剂
    CI994 (Tacedinaline)是一种组蛋白脱乙酰基酶(HDAC)抑制剂,可在活细胞中诱导组蛋白超乙酰化。 了解更多
  5. MGCD0103 (Mocetinostat)

    Catalog No. A10586
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    HDAC 抑制剂
    MGCD0103 (Mocetinostat)是一种苯甲酰胺组蛋白脱乙酰基酶抑制剂,主要抑制组蛋白脱乙酰基酶1(HDAC1),但也抑制HDAC2,HDAC3和HDAC11。 了解更多
  6. Romidepsin (FK228 ,Depsipeptide)

    Catalog No. A11920
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    HDAC 抑制剂
    Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2,IC50分别为1.6 nM和3.9 nM,但相对较弱地分别抑制HDAC4和HDAC6,IC50值为25 nM和79 nM。 了解更多
  7. Tinostamustine (EDO-S101)

    Catalog No. A18342
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    HDAC inhibitor
    EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. 了解更多
  8. Santacruzamate A

    Catalog No. A14236
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    HDAC 抑制剂
    Santacruzamate A (CAY10683)是一种有效的选择性HDAC抑制剂,对HDAC2的IC50为119 pM,选择性是其他HDAC的3600倍以上。 了解更多
  9. Valproic acid

    Catalog No. A17323
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    HDAC inhibitor
    Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. 了解更多
  10. Domatinostat (4SC-202)

    Catalog No. A14354
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    HDAC 抑制剂
    4SC-202是生物利用的苯甲酰胺和人I类组蛋白脱乙酰基酶(HDACs)同工酶1、2和3的抑制剂,具有潜在的抗肿瘤活性。 了解更多
  11. SR-4370

    Catalog No. A16899
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    HDAC 抑制剂
    SR-4370是HDAC抑制剂。SR-4370对HDAC1,HDAC2和HDAC3的IC50值分别为0.5 uM,0.1 uM和0.06 uM。 了解更多
  12. UF010

    Catalog No. A15781
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    HADC 抑制剂
    UF010是一种有效的选择性HADC抑制剂,对于HDAC 3、2、1和8分别具有IC50?0.06 uM,0.1 uM,0.5 uM和1.5 uM。它的选择性是其他HDAC的6倍以上。 了解更多
  13. BRD-6929

    Catalog No. A12511
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    HDAC1/HDAC2 inhibitor
    BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50=?1 and 8 nM), extracted from patent US2018360927. 了解更多
  14. BG45

    Catalog No. A11361
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    HDAC 抑制剂
    BG45是一种HDAC I类抑制剂,对HDAC3具有选择性(IC50 = 289 nM)。它抑制HDAC1,HDAC2和HDAC6的效力大大降低(IC50分别为2、2和> 20μM)。 了解更多
  15. TC-H 106

    Catalog No. A15357
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    HDAC 抑制剂
    TC-H 106是一种慢速,紧密结合的I类HDAC(组蛋白脱乙酰基酶)抑制剂。 了解更多

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