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HIF

Inhibitory Selectivity
Catalog No.Inhibitor Name HIFHIF1Other
A15530FG-2216
****
****
A15359KC7F2
**
**
A11237Roxadustat
A100122-Methoxyestradiol
Microtubule Associated
A14319PX-478 2HCl
A12978BAY 87-2243

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A15358

Chetomin

HIF 抑制剂
Chetomin is reported to be an antibiotic metabolite of Chaetomium spp. which contains bacteriostatic effects on Gram-positive bacteria.
A15359 SALE

KC7F2

HIF 抑制剂
KC7F2 is an inhibitor of HIF-1?? protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K).
A15360

ML 228

HIF activator
ML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay, HIF-1?? nuclear translocation assay, and increased VEGF expression.
A14021

Echinomycin

HIF-1?? 抑制剂
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription
A14367

Oroxylin A

-
Oroxylin A is an O-methylated flavone, It has demonstrated activity as a dopamine reuptake inhibitor and is also a negative allosteric modulator of the benzodiazepine site of the GABAA receptor.
A15530 SALE

FG-2216

HIF-prolyl hydroxylase 抑制剂
FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo,
A15793 SALE

JNJ-42041935

HIF-PHD 抑制剂 II
JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
A12671 SALE

GSK1278863 (Daprodustat)

HIF-prolyl hydroxylase 抑制剂
GSK1278863 is a novel HIF-prolyl hydroxylase inhibitor.
A15895

DASA-58

PKM2 Activator
DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
A14404 SALE

Molidustat

HIF-PH 抑制剂
Molidustat is a novel inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH) which stimulates erythropoietin (EPO) production and the formation of red blood cells.
A14319 SALE

PX-478 HCl

HIF-1alpha 抑制剂
PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.
A12978 SALE

BAY 87-2243

HIF 抑制剂
BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
A12921

HIF-C2

HIF-2 抑制剂
HIF-C2 is a potent and selective allosteric inhibitor of hypoxia inducible factor-2 (HIF-2)
A12883

FM19G11

HIF?? 抑制剂
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), which are transcription factors that respond to changes in available oxygen in the cellular environment.
A11924 SALE

IOX 2

HIF-PHD 抑制剂
IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
A11237 SALE

FG-4592 (Roxadustat)

HIF-PHs 抑制剂
FG-4592 is a novel hypoxia inducible factor prolyl hydroxylase inhibitor, in CKD anemia.
A10012 SALE

2-Methoxyestradiol

Apoptotic, antiproliferative and antiangiogenic agent
2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.
A16181

HIF-2a Translation Inhibitor

HIF-2a translation 抑制剂
HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).

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