Epigenetic Reader Domain

Catalog No.Inhibitor Name Epigenetic Reader Domain
A12729(*)-JQ1
***
A11783I-BET151
*
A12545PFI-1
**
A11440I-BET-762
***
A13956RVX-208
*
A13227SGC-CBP30
****
A13163Bromosporine
****
A13890OTX015
****
A12948UNC1215
**
A13717UNC669
*
A14133GSK1324726A
***
A13749MS436
**
A13068CPI-203
***
A13957PFI-3

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. PFI-1

    Catalog No. A12545
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    BET 抑制剂
    PFI-1是BET溴结构域抑制剂,对BRD2和BRD4表现出抑制活性。 了解更多
  2. Bromosporine

    Catalog No. A13163
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    bromodomain 抑制剂
    Bromosporine是一种针对溴结构域的广谱抑制剂,对于BRD2,BRD4,BRD9和CECR2的IC50分别为0.41μM,0.29μM,0.122μM和0.017μM。 了解更多
  3. GSK 1210151A (I-BET151)

    Catalog No. A11783
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    BET Bromodomain 抑制剂
    GSK 1210151A (I-BET151)是溴结构域和额外末端(BET)家族蛋白BRD2,BRD3和BRD4的新型选择性抑制剂。 了解更多
  4. OTX015

    Catalog No. A13890
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    BET 抑制剂
    OTX015是口服可生物利用的BRD2,BRD3和BRD4的小分子抑制剂(EC50s = 10-19 nM)。 了解更多
  5. Apabetalone (RVX-208)

    Catalog No. A13956
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    BET bromodomain 抑制剂
    RVX-208是一种有效的BET溴结构域抑制剂,对BD2的IC50为0.510 uM,是BD1选择性的170倍。 了解更多
  6. (-)-JQ1

    Catalog No. A14160
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    BET bromodomain 抑制剂
    (-)-JQ1蛋白家族蛋白质的溴结构域和额外末端结构域(BET)家族,包括BRD2,BRD3和BRD4,在许多细胞过程中起着关键作用,包括炎症基因表达,有丝分裂和病毒/宿主相互作用,这是通过控制组蛋白乙酰化的过程来实现的。依赖的染色质复合物。 了解更多
  7. GSK1324726A (I-BET726)

    Catalog No. A14133
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    BET 抑制剂
    GSK1324726A (I-BET726)是一种新型、高效、选择性的BET蛋白小分子抑制剂,对BRD2(IC50 = 41 nM)、BRD3(IC50 = 31 nM)和BRD4(IC50 = 22 nM)具有高度的亲和力。 了解更多

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