CO-1686 (Rociletinib, AVL-301)

目录号: A13028

EGFR 抑制剂

CO-1686 (Rociletinib, AVL-301)

CO-1686 (Rociletinib, AVL-301) Chemical Structure

CAS NO. 1374640-70-6

CO-1686是一种新型的口服靶向共价(不可逆)抑制剂,可抑制表皮生长因子受体(EGFR)的致癌突变形式,目前正在研究用于治疗非小细胞肺癌(NSCLC)。

库存: 现货

规格 价格 数量
5 mg
¥ 350.00
10 mg
¥ 560.00
25 mg
¥ 910.00
50 mg
¥ 1,120.00
10mM * 1mL in DMSO
¥ 1,036.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

CO-1686是一种新型的口服靶向共价(不可逆)抑制剂,可抑制表皮生长因子受体(EGFR)的致癌突变形式,目前正在研究用于治疗非小细胞肺癌(NSCLC)。
In vitro (25°C) DMSO 91 mg/mL (163.8 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18 mL 90 mL 180 mL
0.5 mM 3.6 mL 18 mL 36 mL
1 mM 1.8 mL 9 mL 18 mL
5 mM 0.36 mL 1.8 mL 3.6 mL

*The above data is based on the productmolecular weight 555.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13028
作用机制 Inhibitor (抑制剂)
M. Wt 555.55
Formula C27H28F3N7O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1374640-70-6
Synonyms CO1686; AVL-301; CNX-419 ;AVL 301; AVL301; CNX419
SMILES CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC

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