XL-228

目录号: A13069

IGF-1R, Aurora, FGFR, ABL, SRC 抑制剂

XL-228

XL-228 Chemical Structure

CAS NO. 898280-07-4

XL228是靶向IGF1R,AURORA激酶,FGFR1-3,ABL和SRC家族激酶的蛋白激酶抑制剂。XL228是一种Aurora A抑制剂(IC50,f3 nmol/L),对ABL1(Ki,5 nmol/L)以及BCR-ABL1 T315I(Ki,1.4 nmol/L)激酶显示出有效的生化活性。

库存: 现货

规格 价格 数量
5 mg
¥ 630.00
10 mg
¥ 1,050.00
25 mg
¥ 2,100.00
50 mg
¥ 3,290.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

XL228是靶向IGF1R,AURORA激酶,FGFR1-3,ABL和SRC家族激酶的蛋白激酶抑制剂。XL228是一种Aurora A抑制剂(IC50,f3 nmol/L),对ABL1(Ki,5 nmol/L)以及BCR-ABL1 T315I(Ki,1.4 nmol/L)激酶显示出有效的生化活性。
In vitro DMSO 79 mg/mL (180.55 mM)
Water Insoluble
Ethanol 27 mg/mL (61.7 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.39 mL 96.96 mL 193.93 mL
0.5 mM 3.88 mL 19.39 mL 38.79 mL
1 mM 1.94 mL 9.7 mL 19.39 mL
5 mM 0.39 mL 1.94 mL 3.88 mL

*The above data is based on the productmolecular weight 515.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13069
作用机制 Inhibitor (抑制剂)
M. Wt 515.65
Formula C28H37N9O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 898280-07-4
SMILES CC(C)C1=NOC(=C1)CNC2=NC(=CC(=N2)NC3=NNC(=C3)C4CC4)N5CCN(CC5)C

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