E-7050 (Golvatinib)

目录号: A11396

E-7050 (Golvatinib)

E-7050 (Golvatinib) Chemical Structure

CAS NO. 928037-13-2

E-7050 (Golvatinib)是具有潜在抗肿瘤活性的c-Met(肝细胞生长因子受体)和VEGFR-2(血管内皮生长因子受体-2)酪氨酸激酶的口服生物可利用双重激酶抑制剂。

库存: 现货

规格 价格 数量
10 mg
¥ 770.00
25 mg
¥ 1,540.00
50 mg
¥ 2,660.00
100 mg
¥ 4,760.00
10mM * 1mL in DMSO
¥ 903.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

E-7050 (Golvatinib)是具有潜在抗肿瘤活性的c-Met(肝细胞生长因子受体)和VEGFR-2(血管内皮生长因子受体-2)酪氨酸激酶的口服生物可利用双重激酶抑制剂。
靶点信息
c-Met VEGFR2
14 nM16 nM
In vitro (25°C) DMSO 18 mg/mL (28.4 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.78 mL 78.9 mL 157.81 mL
0.5 mM 3.16 mL 15.78 mL 31.56 mL
1 mM 1.58 mL 7.89 mL 15.78 mL
5 mM 0.32 mL 1.58 mL 3.16 mL

*The above data is based on the productmolecular weight 633.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11396
M. Wt 633.69
Formula C33H37F2N7O4
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 928037-13-2
SMILES CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F

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