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CFTRinh-172

Catalog No. A12897
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CFTR 抑制剂

CFTRinh-172是电压无关的选择性CFTR抑制剂。在2分钟内可逆地抑制CFTR短路电流的 Ki 值为300 nM。了解更多

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- Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851
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PSI-7977

Catalog No. A11529
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HCV Nucleotide 抑制剂

PSI-7977是PSI-7851的氨基磷酸酯前药，PSI-7851是核苷类似物，当磷酸化时，抑制丙型肝炎病毒的RNA依赖性RNA聚合酶(EC50 = 92 nM)。了解更多

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- Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467
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NSC 405020

Catalog No. A13072
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MT1-MMP 抑制剂

NSC-405020是一种膜1型基质金属蛋白酶（MT1-MMP）抑制剂（IC50> 100μmol/ L）。了解更多

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- Kittaka M, .et al. Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts, J Bone Miner Res, 2018, Jan;33(1):167-181 PMID: 28914985
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PD173074

Catalog No. A10703
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FGFR1/VEGFR2 抑制剂

PD173074是有效的，细胞可渗透的和ATP竞争性的FGFR和VEGFR抑制剂。了解更多

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- Cheryl Q.E. Lee, .et al. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast, Stem Cell Reports, 2016, Feb 9; 6(2): 257-272 PMID: 26862703