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搜索结果：“Ligand-gated Ion Channels”

“Ligand-gated Ion Channels”的搜索结果

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Tubacin

Catalog No. A10954
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HDAC6 抑制剂

Tubacin (tubulin acetylation inducer)是一种高效且选择性强，可逆，可透过细胞的HDAC6抑制剂，IC50为4 nM。了解更多

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Cycloheximide (Actidione)

Catalog No. A10036
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Protein Synthesis 抑制剂

Cycloheximide (Actidione)用作选择性抗生素。它抑制腐菌真菌真核生物的蛋白质合成(DNA依赖性RNA)。通过与80S核糖体结合而对皮肤真菌和系统性真菌无效。了解更多

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- Ke Chen, .et al. Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma, Cancer Commun (Lond), 2021, Apr; 41(4): 316-332 PMID: 33591636
- Zhiyuan Qin, .et al. miR-224-5p Contained in Urinary Extracellular Vesicles Regulates PD-L1 Expression by Inhibiting Cyclin D1 in Renal Cell Carcinoma Cells, Cancers (Basel), 2021, Feb 4;13(4):618 PMID: 33557163
- Hua Xu, .et al. Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation, Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
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4E1RCat

Catalog No. A14301
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eIF4F subunit interaction 抑制剂

4E1RCat是eIF4E：eIF4G和eIF4E：4E-BP1相互作用的双重抑制剂。了解更多

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Buthionine Sulphoximine

Catalog No. A16202
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γ-glutamylcysteine synthetase 抑制剂

Buthionine Sulphoximine是一种γ-谷氨酰半胱氨酸合成酶抑制剂，可能用于治疗实体瘤。了解更多

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Valproic acid

Catalog No. A17323
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HDAC inhibitor

Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. 了解更多

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- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
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ACX-362E

Catalog No. A18560
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DNA polymerase IIIC 抑制剂

ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens. 了解更多

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SIS-17

Catalog No. A18463
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HDAC 11 inhibitor

SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. 了解更多

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Valproic acid sodium salt

Catalog No. A10855
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HDAC inhibitor

Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. 了解更多

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Sodium phenylbutyrate

Catalog No. A16714
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HDAC/ER stress inhibitor

Sodium phenylbutyrate is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research. 了解更多

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