微信关注
China
Total item
Cart Subtotal
￥ 0.00 “Ligand-gated Ion Channels”的搜索结果
-
ITI214 free base
Catalog No. A21947 picomolar PDE1 inhibitorITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). 了解更多 -
Zatebradine hydrochloride
Catalog No. A21669 HCN channels inhibitorZatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 ?M. 了解更多 -
Zatebradine
Catalog No. A21364 HCN channels inhibitorZatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 value of 1.96 ?M. 了解更多 -
ML133 hydrochloride
Catalog No. A16620 Kir2 family channels inhibitorML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5. 了解更多 -
Nav1.7-IN-2
Catalog No. A12185 Nav inhibitorNav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM. 了解更多 -
PF-05241328
Catalog No. A20052 Nav1.7 inhibitorPF-05241328 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels (Nav1.7), with an IC50 of 31 nM. 了解更多 -
Nefazodone hydrochloride
Catalog No. A17622 5-HT2 receptors inhibitorNefazodone HCl is an inhibitor of 5-HT2 receptors, SERT, NET, and hERG K+ channels used to treat mood disorders. It decreases immobility time in the forced swim test. 了解更多 -
-
最新产品
SAR-7334 HCl
Catalog No. A17237 TRPC6 inhibitorSAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. 了解更多 -
-
ICA-121431
Catalog No. A13773 NaV1.3 and NaV1.1 channels 抑制剂ICA-121431是人NaV1.3和NaV1.1通道的有效和选择性抑制剂（IC50值分别为13和23 nM）。 了解更多 -
ML-9 hydrochloride
Catalog No. A17856 MLCK inhibitorML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation. 了解更多 -
IACS-010759
Catalog No. A12006 IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). 了解更多 -
Entasobulin
Catalog No. A21027 ??-tubulin polymerization inhibitorEntasobulin is a β-tubulin polymerization inhibitor with potential anticancer activity. 了解更多 -
(±)-Huperzine A
Catalog No. A21003 AChE inhibitor(??)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). 了解更多 -
GSK2795039
Catalog No. A20998 NOX2 inhibitorGSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 reduces apoptosis. 了解更多 -
Seviteronel
Catalog No. A20996 CYP17 lyase inhibitorSeviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. 了解更多 -
Leptomycin B
Catalog No. A20985 nuclear export receptor CRM1 inhibitorLeptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle. 了解更多 -
Aldose reductase-IN-1
Catalog No. A20976 aldose reductase inhibitorAldose reductase-IN-1 is a inhibitor of aldose reductase with IC50 of 28.9 pM. IC50 value: 28.9 pM Target: aldose reductase Detailed information please refer to WO2014113380 A1 and US20130225592. 了解更多 -
CK-666
Catalog No. A20973 Arp2/3 complex inhibitorCK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation. 了解更多 -
Chitinase-IN-1
Catalog No. A20949 insect chitinase and N- acetyl hexosaminidase inhibitorChitinase-IN-1 is a insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide; 50 uM/20 uM compound concentration's inhibitory percentage are 75%/67% for chitinase/N- acetyl-hexosaminidase respectively. 了解更多 -
Raltegravir potassium
Catalog No. A21403 integrase (IN) inhibitorRaltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection. 了解更多 -
Fatostatin
Catalog No. A21153 SREBP activation inhibitorFatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. 了解更多 -
Dantrolene sodium
Catalog No. A17644 Calcium channel proteins inhibitorDantrolene sodium is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ from the sarcoplasm. Dantrolene sodium is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. 了解更多 -
Defactinib hydrochloride
Catalog No. A22003 FAK inhibitorDefactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. 了解更多 -
TAME hydrochloride
Catalog No. A21960 anaphase-promoting complex/cyclosome inhibitorTAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. 了解更多 -
MM-102 TFA
Catalog No. A21941 WDR5/MLL interaction inhibitorMM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki < 1 nM in WDR5 binding assay, which is >200 times more potent than the ARA peptide. 了解更多 -
Vildagliptin dihydrate
Catalog No. A21898 DPP4 inhibitorVildagliptin (LAF237 dihydrate;NVP-LAF 237 dihydrate) is a dipeptidyl peptidase 4 (DPP4) inhibitor that delays the degradation of glucagon-like peptide-1 (GLP-1). 了解更多 -
L-Buthionine-(S,R)-sulfoximine
Catalog No. A21895 g-glutamylcysteine synthetase inhibitorL-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. 了解更多 -
MM-589 TFA
Catalog No. A21892 WDR5 and MLL protein-protein interaction inhibitorMM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. 了解更多 -
Rigosertib
Catalog No. A21868 multi-kinase inhibitorRigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. 了解更多 -
Liarozole dihydrochloride
Catalog No. A21853 CYP450 dependent inhibitorLiarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). 了解更多 -
Rigosertib sodium
Catalog No. A21824 multi-kinase inhibitorRigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. 了解更多 -
RSV604 R enantiomer
Catalog No. A21822 RSV replication inhibitorRSV604 R enantiomer is the R-enantiomer of RSV604. RSV604 is an inhibitor of respiratory syncytial virus (RSV) replication. R-enantiomer is less active against RSV. 了解更多 -
SRI 31215 TFA
Catalog No. A21775 triplex matriptase inhibitorSRI 31215 (TFA), a triplex inhibitor of matriptase, hepsin and hepatocyte growth factor activator (HGFA) with IC50s of 0.69 μM, 0.65 μM, 0.3 μM, blocks pro-HGF activation and thus mimics the activity of HAI-1/2. 了解更多 -
Lexibulin dihydrochloride
Catalog No. A21774 tubulin polymerisation inhibitorLexibulin 2Hcl (CYT-997 2Hcl) is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. 了解更多 -
GSK3368715 dihydrochloride
Catalog No. A21733 PRMT inhibitorGSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). 了解更多 -
KHK-IN-1 hydrochloride
Catalog No. A21674 ketohexokinase (KHK) inhibitorKHK-IN-1 hydrochloride is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM, interacts with Asp-27B in the ATP-binding region of KHK. 了解更多
联系我们
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: sales@adooq.com
Not your Region? View all Distributors
FILTER BY:
Filtering:
- 作用机制: Inhibitor (抑制剂) 删除该内容
购物选项
- 分类
-
- Epigenetics (19)
- Apoptosis (10)
- PI3K / Akt / mTOR (6)
- Protein Tyrosine Kinases (9)
- Angiogenesis (16)
- MAPK (5)
- JAK / Stat (13)
- Cell Cycle (17)
- DNA Damage (9)
- Cytoskeleton (5)
- Cell Metabolism (26)
- Autophagy Signaling (4)
- Immunology & Inflammation (8)
- GPCR / G Protein (6)
- NF-kB/IkB (7)
- TGF-β / Smad (4)
- Neuronal Signaling (9)
- Proteases (22)
- Microbiology (22)
- Stem Cells / Wnt (1)
- Membrane Transporters/Ion Channels (13)
- Endocrinology / Hormones (2)
- Ubiquitin (2)
- PROTACs (1)
- Others (6)
- Natural Products (2)
- Ready to Use Solution (3)
- Products On Sale (14)
- COVID-19 Related Products (3)
- 靶点
-
- CSF1R (1)
- EGFR (1)
- EGFR Exon 19 Deletion (1)
- EGFR L858R (1)
- EGFR T790M (1)
- EGFR wild type (1)
- HDAC (1)
- HDAC1 (1)
- HDAC11 (1)
- HDAC2 (1)
- HDAC6 (1)
- Mdm2 (2)
- Menin-MLL interaction (2)
- p53 (2)
- STAT3 (1)
- STAT5 (1)
ADOOQ 产品质量保证
We promise all products to perform as described.