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搜索结果：“jwh 250”

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Cabazitaxel

Catalog No. A11831
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Microtubule Associated 抑制剂

Cabazitaxel是一种天然紫杉烷的半合成衍生物。Cabazitaxel联合泼尼松是基于多西他赛的激素难治性前列腺癌的治疗选择。了解更多

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- Satoshi Endo, .et al. Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells, J Biochem, 2021, Mar 17 PMID: 33729485
- Tomohiro Nabekura, .et al. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein, Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509
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SB 743921

Catalog No. A10828
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KSP 抑制剂

SB 743921是第二代KSP抑制剂，在癌症的临床前模型中是一种高效有效的治疗剂。了解更多

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Ixabepilone

Catalog No. A11449
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microtubule 抑制剂

Ixabepilone是epothilone B类似物。了解更多

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- Dong-Sheng Cao, .et al. A Multi-Scale Systems Pharmacology Approach Uncovers the Anti-Cancer Molecular Mechanism of Ixabepilone, Eur J Med Chem, 2020, Aug 1;199:112421 PMID: 32428794
- Hoque M, .et al. Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors, Pharmacol Res, 2018, Aug;134:166-178 PMID: 29944980
- APRIL L. RISINGER, .et al. Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time, Anticancer Res, 2015, Nov; 35(11): 5845-5850. PMID: 26504006
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Dynasore

Catalog No. A12726
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Dynamin 抑制剂

dynasore是一种非竞争性的dynamin 1，dynamin 2和线粒体dynamin（Drp1）GTPase活性抑制剂。了解更多

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- KOLAC UK, .et al. Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast Cells, Research Square, 2022, 03 Jun
- Tsukamoto H, .et al. Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKε-IRF3 axis activation, J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187
- Shigetoshi Yokoyama, .et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death, eLife, 2018, 7: e37854 PMID: 30526845
- Naoko Fujii, .et al. Hypotonic Stress-induced Down-regulation of Claudin-1 and -2 Mediated by Dephosphorylation and Clathrin-dependent Endocytosis in Renal Tubular Epithelial Cells, J Biol Chem, 2016, Nov 18; 291(47): 24787-24799 PMID: 27733684
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ARQ 621

Catalog No. A14234
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Eg5 mitotic motor protein 抑制剂

ARQ 621是一种变构选择性Eg5有丝分裂运动蛋白抑制剂。了解更多

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FRAX486

Catalog No. A13691
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PAK 抑制剂

FRAX486是一种小分子PAK抑制剂。了解更多

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- Yukie Yamahashi, .et al. Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning, Mol Psychiatry, 2022, 03 June
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Vc-MMAD

Catalog No. A15273
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Tubulin 抑制剂

Vc-MMAD由ADC接头（Val-Cit）和有效的微管蛋白抑制剂（MMAD）组成，Vc-MMAD是抗体药物偶联物。" 了解更多

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Mps1-IN-1

Catalog No. A11218
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Mps1 抑制剂

Mps1-IN-1是一种高效的选择性Mpls抑制剂，IC50为367 nM。相对于352个成员激酶组，选择性> 1000倍，主要是Alk和Ltk。了解更多

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Cyclo (RGDyK) trifluoroacetate

Catalog No. A15918
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Integrin 抑制剂

Cyclo (RGDyK) trifluoroacetate是一种有效的选择性αVbeta3整联蛋白抑制剂，IC50为20 nM。了解更多

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CWHM12

Catalog No. A15967
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αV integrins 抑制剂

CWHM 12可以抑制所有5个alpha V整联蛋白。CWHM12不仅以与遗传删除方法相同的方式预防纤维化，还可以防止肝和肺中现有纤维化的进展，并逆转了由纤维化对这些器官造成的某些损害。了解更多

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TRx0237 (LMTX) mesylate

Catalog No. A16124
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tau protein aggregation 抑制剂

TRx0237 (LMTX) mesylate是第二代tau蛋白聚集抑制剂，可用于治疗阿尔茨海默氏病（AD）和额颞痴呆。了解更多

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