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  • 搜索结果：“Ligand-gated Ion Channels”

“Ligand-gated Ion Channels”的搜索结果

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  1. WEHI-345
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    WEHI-345

    Catalog No. A21012
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    RIPK2 inhibitor
    WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation. 了解更多
  2. cis-Pralsetinib
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    cis-Pralsetinib

    Catalog No. A21586
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    RET inhibitor
    cis-Pralsetinib (cis-BLU-667) is a highly potent and selective inhibitor of rearranged during transfection (RET), with IC50s ranging from 0.3 to 0.4 nM for WT RET and four enzyme variants (V804L, V804M, M918T, CCDC6-RET), and with broad, robust and anti-tumor activity against multiple RET-driven solid tumor types. 了解更多
  3. RO8994
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    RO8994

    Catalog No. A20865
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    MDM2 inhibitor
    RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). 了解更多
  4. MI-1061
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    MI-1061

    Catalog No. A18450
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    MDM2 inhibitor
    MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity. 了解更多
  5. PK68
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    PK68

    Catalog No. A18582
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    RIPK1 inhibitor
    PK68 is a potent and selective type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis. 了解更多
  6. RO-5963
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    RO-5963

    Catalog No. A18813
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    MDM2/MDMX inhibitor
    RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53 with IC50s of ~17 nM and ~24 nM, respectively. 了解更多
  7. ML311
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    ML311

    Catalog No. A18364
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    Mcl-1/Bim interaction 抑制剂
    ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction 了解更多
  8. p53 and MDM2 proteins-interaction-inhibitor racemic
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    p53 and MDM2 proteins-interaction-inhibitor racemic

    Catalog No. A15202
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    p53-MDM2 interaction 抑制剂
    p53和MDM2蛋白相互作用抑制剂消旋体是p53和MDM2蛋白之间相互作用的抑制剂。 了解更多
  9. p53 and MDM2 proteins-interaction-inhibitor chiral
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    p53 and MDM2 proteins-interaction-inhibitor chiral

    Catalog No. A15201
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    p53-MDM2 interaction 抑制剂
    p53和MDM2蛋白相互作用抑制剂手性是p53和MDM2蛋白之间相互作用的抑制剂。 了解更多
  10. Salubrinal
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    Salubrinal

    Catalog No. A12676
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    eIF2α dephosphorylation 抑制剂
    Salubrinal是细胞磷酸酶复合物的可渗透细胞的选择性抑制剂，可将真核翻译起始因子2亚基α（eIF2α）磷酸化。保护细胞免受内质网应激诱导的细胞凋亡（EC50?15 μM）。 了解更多

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  1. Bcl-2 Family (1)
  2. p53 (2)
  3. MDM2 (5)
  4. PERK (1)
  5. RIP Kinase (2)
  6. c-Ret (1)
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  1. Mdm2 (2)
  2. p53 (2)
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