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AT13148

Catalog No. A12464
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multi-AGC kinase 抑制剂

AT13148是一种新型多AGC激酶抑制剂，具有强大的药效和抗肿瘤活性，与其他AKT抑制剂相比，具有独特的作用机理。了解更多

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ON-01910 (rigosertib)

Catalog No. A10673
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PLK 抑制剂

ON-01910 (rigosertib)通过涉及PI3K/AKT抑制和氧化应激诱导的双重作用机制对慢性淋巴细胞白血病细胞具有选择性的细胞毒性。了解更多

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SNX-2112

Catalog No. A11189
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Hsp90 抑制剂

SNX-2112是目前在临床试验中具有抗癌特性的热激蛋白90（Hsp90）抑制剂。SNX-2112通过Akt/mTOR/p70S6K抑制以时间和剂量依赖的方式诱导自噬。SNX-2112在人黑素瘤A-375细胞中诱导明显的凋亡和自噬，可能是有效的靶向治疗剂。了解更多

Product Citations (2)

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- Michael Heider, .et al. The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma, Mol Cell, 2021, Mar 18;81(6):1170-1186 PMID: 33571422
- Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113
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Artesunate

Catalog No. A10087
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cytochrome oxidase 抑制剂

Artesunate是用于治疗疟疾的青蒿素的半合成衍生物。它也被证明可以有效对抗其他寄生虫，例如肝吸虫。青蒿琥酯还显示出针对不同肿瘤类型的癌细胞系的细胞毒性作用。青蒿琥酯已显示出通过抑制类风湿关节炎成纤维细胞样滑膜细胞中的NF-B和PI3激酶/ Akt信号通路来抑制TNF诱导的促炎细胞因子的产生。了解更多

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BX-795

Catalog No. A11148
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PDK-1 抑制剂

BX-795是有效的PDK1抑制剂，可阻断肿瘤细胞中的PDK1/Akt信号传导并抑制培养物中多种肿瘤细胞系的锚定依赖性生长或诱导凋亡。了解更多

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- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
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TAK-733

Catalog No. A11040
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MEK 抑制剂

TAK-733是一种有效的，选择性的MEK变构抑制剂，作用于MEK1，IC50为3.2 nM，抑制Abl1，AKT3，c-RAF，CamK1，CDK2及c-Met等活性。了解更多

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KU-55933

Catalog No. A10506
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ATM 抑制剂

KU-55933是ATM抑制剂，通过抑制细胞增殖，并通过阻断Akt过度激活的癌细胞中的Akt诱导凋亡。了解更多

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- Mariko Shikata, .et al. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K/Akt Activation and Its Impact on γ-H2AX Generation, Chem Res Toxicol, 2021, Dec 20;34(12):2512-2521 PMID: 34784199
- Masaya Igase, .et al. Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma, Mol Ther Oncolytics, 2019, vol 15 PMID: 31650025
- Hayakawa K, .et al. Planar compression of extracellular substrates induces S phase arrest via ATM-independent CHK2 activation, Biochem Biophys Res Commun, 2018, Dec 2;506(4):983-989 PMID: 30404732
- Chwastek J, .et al. The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D, Int J Biochem Cell Biol, 2017, Jun;87:38-53 PMID: 28341201