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搜索结果：“rasgap ras p21”

“rasgap ras p21”的搜索结果

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PSI-6206

Catalog No. A11530
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HCV RNA polymerase 抑制剂

PSI-6206是PSI-6130的脱氨基衍生物，是有效的HCV RNA依赖性RNA聚合酶抑制剂，靶向NS5B聚合酶。了解更多

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Ellipticine

Catalog No. A13780
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DNA topoisomerase II 抑制剂

Ellipticine是DNA嵌入剂和DNA拓扑异构酶II抑制剂。了解更多

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- Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
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Ziprasidone

Catalog No. A15286
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5-HT/dopamine receptor 拮抗剂

Ziprasidone是5-HT（5-羟色胺）和多巴胺受体拮抗剂的组合，具有抗精神病活性。了解更多

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Bikinin

Catalog No. A15526
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GSK-3 抑制剂

Bikinin是植物GSK-3/Shaggy-like激酶的有效抑制剂。激活BR受体下游的BR信号传导。了解更多

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G007-LK

Catalog No. A15528
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TNKS 抑制剂

G007-LK对坦科聚合酶1和2具有很高的选择性，生化IC50值分别为46 nM和25 nM，细胞IC50值为50 nM，并具有出色的小鼠药代动力学特征，了解更多

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- Dominic B. Bernkopf, .et al. An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy, Nat Commun, 2019, 10:4251 PMID: 31534175
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DEL-22379

Catalog No. A15802
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ERK 抑制剂

DEL-22379是一种有效的选择性ERK二聚体抑制剂，可抑制ERK二聚体而不影响ERK磷酸化，阻止由RAS-ERK途径癌基因驱动的肿瘤发生。了解更多

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AZ6102

Catalog No. A15873
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TNKS1/2 抑制剂

AZ6102是有效的TNKS1/2抑制剂，对其他PARP家族酶具有100倍的选择性，对DLD-1细胞中Wnt途径的抑制作用的IC50为5 nM。了解更多

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Madrasin

Catalog No. A16063
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Madrasin是一种有效的细胞渗透性剪接抑制剂，可干扰剪接体组装的早期阶段。了解更多

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CP21R7

Catalog No. A16230
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GSK-3β 抑制剂

CP21R7是有效的选择性GSK-3β抑制剂。了解更多

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Kobe0065

Catalog No. A13135
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Ras-Raf interaction 抑制剂

Kobe0065抑制锚定依赖性和非依赖性生长，阻断MEK / ERK活性并诱导H-rasG12V转化的NIH3T3细胞凋亡。了解更多

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Pyridostatin

Catalog No. A12717
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Pyridostatin是一种G-quadruplexe稳定剂，无细胞试验中Kd为490 nM，其以一系列原癌基因，包括c-kit，K-ras 和 Bcl-2为靶点。可通过诱导复制和转录依赖性DNA损伤来促进人类癌细胞的生长停滞。了解更多

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RSL3

Catalog No. A15865
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Ferroptosis inhibitor

RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. 了解更多

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- Sampilvanjil A, .et al. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells, Am J Physiol Heart Circ Physiol, 2020, Mar 1;318(3):H508-H518 PMID: 31975626
- Fujiki K, .et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
- Samantha W. Alvarez, .et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis, Nature, 2017, Nov 30; 551(7682): 639-643 PMID: 29168506
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Pifithrin-alpha

Catalog No. A12451
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p53 抑制剂

Pifithrin-alpha是p53介导的细胞凋亡和p53依赖性基因转录（如细胞周期蛋白G，p21/waf1和mdm2表达）的可逆抑制剂。了解更多

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K-Ras(G12C) inhibitor 6

Catalog No. A14103
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K-Ras(G12C) 抑制剂

K-Ras(G12C) inhibitor 6 是致癌性K-Ras（G12C）的不可逆抑制剂，颠覆了天然核苷酸的偏爱性，使GDP优于GTP。了解更多

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K-Ras(G12C) inhibitor 12

Catalog No. A14227
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K-Ras(G12C) 抑制剂

K-Ras(G12C) inhibitor 12 是致癌性K-Ras（G12C）的变构抑制剂。了解更多

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