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搜索结果：“rasgap ras p21”

“rasgap ras p21”的搜索结果

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Amonafide (AS1413)

Catalog No. A10071
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Topoisomerase 抑制剂

Amonafide (AS1413)是一种DNA插入剂和拓扑异构酶II抑制剂，是治疗肿瘤疾病的抗肿瘤药物之一。了解更多

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- Veronica Rendo, .et al. Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy, Nat Commun, 2020, 11: 1308 PMID: 32161261
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Adriamycin

Catalog No. A10041
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topoisomerase II 抑制剂

Adriamycin是一种蒽环类抗生素，它通过插入DNA起作用，而最严重的副作用是危及生命的心脏损害。它通常用于治疗多种癌症，包括血液系统恶性肿瘤，多种类型的癌症和软组织肉瘤。了解更多

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- Sanaz Naghibi, .et al. Brush-like Polymer Prodrug with Aggregation-Induced Emission Features for Precise Intracellular Drug Tracking, Biosensors (Basel), 2022, May 29;12(6):373 PMID: 35735521
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Irinotecan HCl Trihydrate (Campto)

Catalog No. A10479
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Topoisomerase 抑制剂

Irinotecan (CPT 11)是喜树碱家族的一种化合物，是参与细胞DNA复制和转录的拓扑异构酶1的抑制剂。了解更多

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Rasagiline

Catalog No. A11111
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MAO B 抑制剂

Rasagiline是MAO-B（单胺氧化酶-B）的选择性不可逆抑制剂。了解更多

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S/GSK1349572 (Dolutegravir)

Catalog No. A11068
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HIV integrase 抑制剂

S/GSK1349572是有效的下一代HIV整合酶抑制剂，并通过60个整合酶突变分子克隆证实了优异的耐药性。了解更多

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- Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1
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Topotecan HCl (Hycamtin)

Catalog No. A10939
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DNA topoisomerase I 抑制剂

Topotecan HCl (Hycamtin)是一种化学治疗剂，是拓扑异构酶抑制剂。了解更多

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Marbofloxacin

Catalog No. A10557
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Topoisomerase 抑制剂

Marbofloxacin是有效的第三代氟喹诺酮类抗生素，通过抑制细菌DNA复制起作用。了解更多

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Kaempferol

Catalog No. A10495
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ERRα and ERRγ inverse 激动剂

Kaempferol被发现抑制Ki为0.3-0.5 μM的牛主动脉肌球蛋白轻链激酶，并且还被发现通过新的ERK-NFκB-cMyc-p21途径抑制VEGF表达和体外血管生成。了解更多

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Synephrine (Oxedrine)

Catalog No. A10882
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Adrenergic Receptor 激动剂

Synephrine (Oxedrine)是一种通常用于减肥的胺化合物。了解更多

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Raltegravir (MK-0518)

Catalog No. A10775
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HIV-1 integrase 抑制剂

Raltegravir (MK-0518)靶向整合酶，这是一种HIV酶，可将病毒遗传物质整合到人类染色体中，这是HIV发病机理中的关键步骤。了解更多

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- Michal S Barski, .et al. Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures, Nat Commun, 2021, Aug 17;12(1):4996 PMID: 34404793
- Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1
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Decitabine

Catalog No. A10292
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DNA Methyltransferase 抑制剂

Decitabine是一种次甲基化剂，它通过抑制DNA甲基转移酶来使DNA次甲基化。了解更多

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- Borbala Szabo, .et al. Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma, J Clin Endocrinol Metab, 2022, Sep 5;dgac496 PMID: 36059148
- Sangni Qian, .et al. Hypermethylation of tumor suppressor lncRNA MEF2C-AS1 frequently happened in patients at all stages of colorectal carcinogenesis, Clin Epigenetics, 2022, Sep 5;14(1):111 PMID: 36064442
- Borb??la Szab??, .et al. Demethylation status of somatic DNA extracted from pituitary neuroendocrine tumors indicates proliferative behavior, J Clin Endocrinol Metab, 2020, Jun 1;105(6):dgaa156 PMID: 32232382
- Bracha Shraibman, .et al. Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy, Mol Cell Proteomics, 2016, Sep; 15(9): 3058-3070 PMID: 27412690
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Moxifloxacin HCl

Catalog No. A10609
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Topoisomerase 抑制剂

Moxifloxacin HCl是一种喹诺酮/氟喹诺酮类抗菌剂。了解更多

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- Hiroshi Arakawa, .et al. Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs, Biopharm Drug Dispos, 2016, Jan;37(1):39-45 PMID: 26590007
- Arisa Higa, .et al. Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements, Fundam. Toxicol. Sci, 2016, 3(2): 47-53
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Norfloxacin (Norxacin)

Catalog No. A10652
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Topoisomerase 抑制剂

Norfloxacin(Norxacin)是一种广谱抗生素。了解更多

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AZD1152-HQPA (Barasertib)

Catalog No. A10109
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Aurora Kinase B 抑制剂

AZD1152-HQPA (Barasertib)是Aurora B的高效抑制剂，Ki值分别为0.36（Aurora B）和1369 nM（Aurora A），与一组其他50种激酶相比具有很高的特异性。了解更多

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- Sakamoto K, .et al. Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response, Leukemia, 2018, May 23 PMID: 29795241
- Jennifer M. Sahni, .et al. Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases, J Biol Chem, 2016, Nov 4; 291(45): 23756-23768 PMID: 27650498
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Tipifarnib (Zarnestra)

Catalog No. A10935
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FTase 抑制剂

Tipifarnib (Zarnestra)是一种法尼基转移酶抑制剂，可在激酶途径变得过度活跃之前的翻译后修饰步骤中抑制Ras激酶。了解更多

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- Xiaoming Liu, .et al. Small extracellular vesicles induce resistance to anti-GD2 immunotherapy unveiling tipifarnib as an adjunct to neuroblastoma immunotherapy, J Immunother Cancer, 2022, Apr;10(4):e004399 PMID: 35483745

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