Ras Homolog Gene Family Member A Human Recombinant 了解更多

RAB5B, Member RAS Oncogene Family Human Recombinant 了解更多

RAB6A, Member RAS Oncogene Family Human Recombinant 了解更多

RAB1B, Member RAS Oncogene Family Human Recombinant 了解更多

APS-2-79是RAF通过直接结合KSR活性位点而使MEK磷酸化的拮抗剂。 了解更多

XRP44X是Ras-Net（Elk-3）途径抑制剂（IC50 = 10-20 nM）。间接抑制Erk1/2激活上游的净磷酸化。 了解更多

RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS. 了解更多

Pyridostatin是一种G-quadruplexe稳定剂，无细胞试验中Kd为490 nM，其以一系列原癌基因，包括c-kit，K-ras 和 Bcl-2为靶点。可通过诱导复制和转录依赖性DNA损伤来促进人类癌细胞的生长停滞。 了解更多

Kobe0065抑制锚定依赖性和非依赖性生长，阻断MEK / ERK活性并诱导H-rasG12V转化的NIH3T3细胞凋亡。 了解更多

Balamapimod (MKI-833)是Ras/Raf/MEK抑制剂。 了解更多

Diazepinomicin，也称为TLN-4601，是具有潜在抗肿瘤活性的RAS/RAF/MAPK信号传导途径的小分子抑制剂。 了解更多

Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity. 了解更多

CRANAD-2 is a curcumin-derivatized near-infrared (NIR) probe that meets all the requirements for a NIR contrast agent for the detection of Abeta plaques both in vitro and in vivo. 了解更多

G244-LM is a potent and specific tankyrase 1/2 inhibitor that inhibits Wnt signaling. 了解更多

SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor with IC50 of 1.2 μM. SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells. 了解更多

TTK21 is a CBP/p300 histone acetyltransferase activator. 了解更多

ERDRP-0519 is an orally available inhibitor of polymerase that shows efficacy against a lethal morbillivirus infection in a large animal model. 了解更多

SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with IC50 of 50 nM. 了解更多

Aka Lumine, a luciferin analogue, is a luciferase substrate emitting red, green, and blue light. The longest emission wavelength of Aka Lumine is recorded at 675 nm, which is within the NIR region. 了解更多

JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 ?M, 2.8 ?M, and 5.0??M for human NNMT, monkey NNMT and mouse NNMT, respectively. 了解更多

Enpp-1-IN-1 is a Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitor extracted from patent WO2019046778, Example 55. 了解更多

Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor. 了解更多

Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 ?M. Lavendustin B is also a weak inhibitor of tyrosine kinases. 了解更多

Eurycomanone could increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. 了解更多

FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. 了解更多

TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. TAE-1 inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively. 了解更多

N-(beta-ketocaproyl)-L-Homoserine lactone (N-(Ketocaproyl)-L-homoserine lactone, N-(β-Ketocaproyl)-L-hoMoserine lactone) is an autoinducer of P. fischeri luciferase and a component of quorum regulatory sensing. 了解更多

BTZO-1 is an activator of the glutathione S-transferase Ya subunit (GST Ya) gene ARE by interacting with MIF. 了解更多

5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner. 了解更多

CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. 了解更多

Astramembrangenin (Cycloastragenol) is a compound isolated from the roots of Astragalus kuhitangi (Nevski) Sirj. 了解更多

GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. 了解更多

Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc. 了解更多

Topovale, also known as ARC-111, is a potent topoisomerase I inhibitor. 了解更多

WM 3835 is a lysine acetyltransferase HBO1 (KAT7) inhibitor. 了解更多

CP-609754, also known as CP-609,754, LNK 754 and OSI 754, is a potent farnesyltransferase inhibitor with potential anticancer activity. 了解更多

EMAC10101d is a potent and selective inhibitor of Carbonic Anhydrase Isoform toward hCA II with an inhibitory activity in the low nanomolar range. Ki of 8.1 nM 了解更多

ARS-1323-Alkyne is a novel KRASG12C occupancy probe. 了解更多

Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.8 nM. 了解更多

Distigmine Bromide, also known as Ubretid and BC-51, is an acetylcholinesterase inhibitor used for the treatment of underactive neurogenic bladder and myasthenia gravis. 了解更多

Tracazolate is a pyrazolopyridine anxiolytic known to interact with gamma-aminobutyric acid (GABA)(A) receptors, adenosine receptors, and phosphodiesterases. 了解更多

THPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species. 了解更多

Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation. 了解更多

Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium. 了解更多

(S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells. 了解更多

Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. 了解更多

AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. 了解更多

Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. 了解更多

UNC0379 TFA is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM; selective over 15 other methyltransferases. 了解更多