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Gemcabene calcium
Catalog No. A21421 Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity. 了解更多 -
Frentizole
Catalog No. A21335 Frentizole, an FDA-approved immunosuppressive drug, is a novel inhibitor of the Aβ-ABAD interaction. 了解更多 -
Pozanicline
Catalog No. A21318 Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM. 了解更多 -
Pasireotide
Catalog No. A21304 Pasireotide(SOM 230) is a stable cyclohexapeptide somatostatin mimic that exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9 respectively). 了解更多 -
Cholecalciferol
Catalog No. A21284 Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. 了解更多 -
Dolastatin 10
Catalog No. A21273 Dolastatin 10 (DLS 10) is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization. 了解更多 -
Carbendazim
Catalog No. A21261 Carbendazim is a broad-spectrum benzimidazole fungicide which can be used to control a broad range of diseases on arable crops, fruits, vegetables, ornamentals and medicinal herbs. 了解更多 -
Elacytarabine
Catalog No. A21244 Elacytarabine (CP 4055) is a lipid-conjugated derivative of the nucleoside analog cytarabine. Elacytarabine (CP 4055) is an antineoplastic drug with cytotoxicity in solid tumors. 了解更多 -
BCR-ABL-IN-2
Catalog No. A21043 inhibitor of BCR-ABL1 tyrosine kinaseBCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively. 了解更多 -
Ombrabulin hydrochloride
Catalog No. A21040 Ombrabulin hydrochloride is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells. 了解更多 -
GNF179 Metabolite
Catalog No. A21032 GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. 了解更多 -
Vericiguat
Catalog No. A21031 guanylate cyclase stimulatorVericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator. 了解更多 -
Tirabrutinib
Catalog No. A21019 BTK inhibitorTirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM. 了解更多 -
YF-2
Catalog No. A21018 histone acetyltransferase activatorYF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease. 了解更多 -
Ilorasertib
Catalog No. A20982 ATP-competitive multitargeted kinase inhibitorIlorasertib (ABT-348) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. 了解更多 -
CK-666
Catalog No. A20973 Arp2/3 complex inhibitorCK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation. 了解更多 -
25,26-Dihydroxyvitamin D3
Catalog No. A20950 25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity. 了解更多 -
SEL120-34A HCl
Catalog No. A21485 CDK8 inhibitorSEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. 了解更多 -
Veliparib dihydrochloride
Catalog No. A21356 PARP inhibitorVeliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. 了解更多 -
Talarozole
Catalog No. A21124 retinoic acid metabolism blocking agentTalarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively. 了解更多 -
Aripiprazole (D8)
Catalog No. A22004 human 5-HT1A receptor partial agonistAripiprazole D8 (OPC-14597 D8) is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. 了解更多 -
Ralfinamide mesylate
Catalog No. A22002 Na+ channel blockerRalfinamide mesylate (FCE-26742A mesylate) is an orally available Na+ channel blocker derived from α-aminoamide, with function of suppressing pain. 了解更多 -
Aprocitentan
Catalog No. A21999 dual ETA/ETB antagonistAprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. 了解更多 -
Carotegrast
Catalog No. A21997 α4 integrin receptor inhibitorCarotegrast is an orally available α4 integrin receptor inhibitor with anti-inflammatories activities. 了解更多 -
Ziprasidone D8
Catalog No. A21989 5-HT / dopamine receptor antagonistZiprasidone D8 is deuterium labeled Ziprasidone, which is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. 了解更多 -
all-trans-4-Oxoretinoic acid
Catalog No. A21978 all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). 了解更多 -
Haloperidol D4'
Catalog No. A21971 dopamine D2 receptor antagonistHaloperidol D4' is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist. 了解更多 -
Haloperidol D4
Catalog No. A21961 dopamine D2 receptor antagonistHaloperidol D4 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist. 了解更多 -
Bambuterol
Catalog No. A21955 beta-adrenoceptor agonistBambuterol ((??)-Bambuterol; KWD-2183) is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline. 了解更多 -
MT-7716 free base
Catalog No. A21928 non-peptide nociceptin receptor (NOP) agonistMT-7716 free base (W-212393) is a selective non-peptide nociceptin receptor (NOP) agonist and promising potential treatment drug for alcohol abuse and relapse prevention. 了解更多 -
MBC-11 trisodium
Catalog No. A21925 MBC-11 trisodium is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. Has potential to treat tumor-induced bone disease (TIBD). 了解更多 -
Tebanicline hydrochloride
Catalog No. A21918 nAChR modulatorTebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. 了解更多 -
Aliskiren D6 Hydrochloride
Catalog No. A21913 direct renin inhibitorAliskiren D6 Hydrochloride (CGP 60536 D6 Hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor with IC50 of 1.5 nM. 了解更多
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