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SSR-241586
Catalog No. A20773 neurokinin receptors antagonistSSR-241586 is an antagonist of neurokinin receptors. SSR-241586 is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS). 了解更多 -
Mertansine
Catalog No. A20772 microtubulin inhibitorMertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. 了解更多 -
SB-616234A
Catalog No. A20764 5-HT1B receptor antagonistSB-616234A is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity. 了解更多 -
Naquotinib mesylate
Catalog No. A20762 EGFR inhibitorNaquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR. 了解更多 -
Fmoc-Val-Cit-PAB-MMAE
Catalog No. A20751 drug-linker conjugate for ADCFmoc-Val-Cit-PAB-MMAE consists the ADCs linker (Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE). Fmoc-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC. 了解更多 -
Acetylene-linker-Val-Cit-PABC-MMAE
Catalog No. A20749 drug-linker conjugate for ADCAcetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) consists the ADCs linker (Acetylene-linker-Val-Cit-PABC) and potent tubulin inhibitor (MMAE). Acetylene-linker-Val-Cit-PABC-MMAE (LCB14-0602) is a drug-linker conjugate for ADC. 了解更多 -
mDPR-Val-Cit-PAB-MMAE
Catalog No. A20747 drug-linker conjugate for ADCmDPR-Val-Cit-PAB-MMAE consists the ADCs linker (mDPR-Val-Cit-PAB) and potent tubulin inhibitor (MMAE). mDPR-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC. 了解更多 -
Pumosetrag Hydrochloride
Catalog No. A20692 5-HT3 partial agonistPumosetrag Hydrochloride (MKC-733; DDP-733) is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease. 了解更多 -
5-FAM
Catalog No. A20660 fluorescent derivatization reagent5-FAM (5-Carboxyfluorescein) contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Fluorescein is the most common fluorescent derivatization reagent for labeling biomolecules. 了解更多 -
Vipivotide tetraxetan Linker
Catalog No. A20653 Vipivotide tetraxetan Linker (PSMA-617 Linker) is a nonclaevable peptide linker for synthesis of Vipivotide tetraxetan (PSMA-617). 了解更多 -
Adomeglivant
Catalog No. A20647 glucagon receptor antagonistAdomeglivant is a potent and selective glucagon receptor antagonist that is used in clinical trial for type 2 diabetes mellitus. 了解更多 -
Vaborbactam
Catalog No. A20638 β-lactamase inhibitorVaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor. 了解更多 -
Calcitriol Impurities A
Catalog No. A20633 Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). 了解更多 -
Methyl vanillate
Catalog No. A20626 Wnt/β-catenin activatorMethyl vanillate, one of the ingredients in Hovenia dulcis Thunb, is a Wnt/β-catenin pathway activator. A benzoate ester that is the methyl ester of vanillic acid. It has a role as an antioxidant and a plant metabolite. 了解更多 -
Azeliragon
Catalog No. A20622 RAGE inhibitorAzeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression in patients with mild Alzheimer??s disease (AD). Azeliragon also can cross the blood-brain barrier (BBB). 了解更多 -
TAK-220
Catalog No. A20618 -
L-Pyroglutamic acid
Catalog No. A20617 L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism. 了解更多 -
CCT-251921
Catalog No. A20610 CDK8 inhibitorCCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM. 了解更多 -
10-Deacetyl-7-xylosyl paclitaxel
Catalog No. A20602 10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features. 了解更多 -
LX2761
Catalog No. A20597 SGLT1/SGLT2 inhibitorLX2761 is chemically stable and potent inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 in vitro with IC50s of 2.2 nM and 2.7nM for hSGLT1 and hSGLT2, but displays specific SGLT1 inhibition in the gastrointestinal (GI) tract. 了解更多 -
PF-01247324
Catalog No. A20596 Nav1.8 channel blockerPF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker with an IC50 of 196 nM for recombinant human Nav1.8 channel. 了解更多 -
L-Cysteinesulfinic acid
Catalog No. A20585 metabotropic glutamate receptors agonistL-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively. 了解更多 -
JQ-1 (carboxylic acid)
Catalog No. A20579 BRD4 inhibitorJQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively. 了解更多 -
SPDP
Catalog No. A20578 short-chain crosslinkerSPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs). 了解更多 -
Dansyl glutathione
Catalog No. A20573 Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites. 了解更多 -
Allopurinol riboside
Catalog No. A20572 Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites. 了解更多 -
MC-Val-Cit-PAB
Catalog No. A20571 MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker. 了解更多 -
Isoguvacine hydrochloride
Catalog No. A20563 -
3-(Methylthio)propionic acid
Catalog No. A20556 3-(Methylthio)propionic acid is an intermediate in the methionine metabolism. 了解更多 -
Futibatinib
Catalog No. A20550 FGFR inhibitorFutibatinib (TAS-120) is an orally bioavailable, highly selective, and irreversible FGFR inhibitor. 了解更多 -
Mal-amido-PEG8-C2-acid
Catalog No. A20548 nonclaevable ADC linkerMal-amido-PEG8-C2-acid (example 142) is a nonclaevable ADC linker, extracted from patent US2018339985. 了解更多 -
OABK hydrochloride
Catalog No. A20546 OABK hydrochloride is a small-molecule switch that can be used to control protein activity. 了解更多
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