Bcl-2 Family

Catalog No.Inhibitor Name Bcl-2Bcl-BBcl-wBcl-xLMcl-1A1BaxOther
A10255ABT-737
****
*
***
***
A10022Navitoclax (ABT-263)
****
****
****
**
**
A10665Obatoclax Mesylate
***
A10955TW-37
***
*
***
A12500Venetoclax
****
***
****
A15004AT101
**
**
***
A11448HA14-1
*
A12823Sabutoclax
**
**
***
**
A15545A-1210477
****
A14222UMI-77
**
A11988Gambogic Acid
*
*
****
*
*
*
Caspase
A12743BM-1074
****
****
A13327WEHI-539 hydrochloride
****
A15821BDA-366
***
A16061BH3I-1
*
p53
A16112A-1155463
****
A16190A-1331852
****
A16314Apogossypolone (ApoG2)

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. ABT-263 (Navitoclax)

    Catalog No. A10022
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    Bcl-2 抑制剂
    ABT-263 (Navitoclax)是一种有效的Bcl-2家族抑制剂 (Bcl-2,Bcl-xL和Bcl-w的Ki <1 nmol/L)。ABT-263对Bcl- xL,Bcl-2和Bcl-w,( Ki≤1nmol/ L) 维持高亲和力,但与Mcl-1和A1的结合更弱。 了解更多

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