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￥ 0.00 Bcl-2 Family
| Catalog No. | Inhibitor Name | Bcl-2 | Bcl-B | Bcl-w | Bcl-xL | Mcl-1 | A1 | Bax | Other |
|---|---|---|---|---|---|---|---|---|---|
| A10255 | ABT-737 | **** | * | *** | *** | ||||
| A10022 | Navitoclax (ABT-263) | **** | **** | **** | ** | ** | |||
| A10665 | Obatoclax Mesylate | *** | |||||||
| A10955 | TW-37 | *** | * | *** | |||||
| A12500 | Venetoclax | **** | *** | **** | |||||
| A15004 | AT101 | ** | ** | *** | |||||
| A11448 | HA14-1 | * | |||||||
| A12823 | Sabutoclax | ** | ** | *** | ** | ||||
| A15545 | A-1210477 | **** | |||||||
| A14222 | UMI-77 | ** | |||||||
| A11988 | Gambogic Acid | * | * | **** | * | * | * | Caspase | |
| A12743 | BM-1074 | **** | **** | ||||||
| A13327 | WEHI-539 hydrochloride | **** | |||||||
| A15821 | BDA-366 | *** | |||||||
| A16061 | BH3I-1 | * | p53 | ||||||
| A16112 | A-1155463 | **** | |||||||
| A16190 | A-1331852 | **** | |||||||
| A16314 | Apogossypolone (ApoG2) |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Gambogic acid
Catalog No. A11988 Bcl-2 抑制剂Gambogic acid是从藤黄汉树中分离出的天然产物。藤黄酸激活半胱氨酸蛋白酶，EC50为0.78-1.64μM，并竞争性抑制Bcl-XL，Bcl-2，Bcl-W，Bcl-B，Bfl-1和Mcl-1，IC50为1.47、1.21、2.02、0.66、1.06和 分别为0.79μM。 了解更多 -
Obatoclax mesylate (GX15-070)
Catalog No. A10665 Bcl-2 抑制剂Obatoclax Mesylate (GX15-070)是一种Bcl-2拮抗剂，拮抗所有抗凋亡Bcl-2家族蛋白（平均IC50，3 umol/L），包括Mcl-1（IC50，2.9 umol/L）和Bfl-1（IC50，5 umol/L）。 了解更多
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