CL-387785 (EKI-785)

目录号: A13146

EGFR 抑制剂

CL-387785 (EKI-785)

CL-387785 (EKI-785) Chemical Structure

CAS NO. 194423-06-8

CL-387785是EGFR的不可逆抑制剂,IC50为370+/-120 pM;能够在功能水平上克服由T790M突变引起的抗药性。

库存: 现货

规格 价格 数量
10 mg
¥ 840.00
25 mg
¥ 1,750.00
50 mg
¥ 3,150.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

CL-387785是EGFR的不可逆抑制剂,IC50为370+/-120 pM;能够在功能水平上克服由T790M突变引起的抗药性。
靶点信息
EGFR
370 pM
In vitro DMSO Warmed: 61 mg/mL (160 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.23 mL 131.15 mL 262.31 mL
0.5 mM 5.25 mL 26.23 mL 52.46 mL
1 mM 2.62 mL 13.12 mL 26.23 mL
5 mM 0.52 mL 2.62 mL 5.25 mL

*The above data is based on the productmolecular weight 381.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13146
作用机制 Inhibitor (抑制剂)
M. Wt 381.23
Formula C18H13BrN4O
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 194423-06-8
Synonyms WAY-EKI 785, CL387785, CL 387785, EKI785, WAY-EKI785, EKI 785, EKI-785
SMILES CC#C/C(O)=N/C1=CC(C(NC2=CC=CC(Br)=C2)=NC=N3)=C3C=C1

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