Gambogic acid

目录号: A11988

Bcl-2 抑制剂

Gambogic acid

Gambogic acid Chemical Structure

CAS NO. 2752-65-0

Gambogic acid是从藤黄汉树中分离出的天然产物。藤黄酸激活半胱氨酸蛋白酶,EC50为0.78-1.64μM,并竞争性抑制Bcl-XL,Bcl-2,Bcl-W,Bcl-B,Bfl-1和Mcl-1,IC50为1.47、1.21、2.02、0.66、1.06和 分别为0.79μM。

库存: 现货

规格 价格 数量
10 mg
¥ 490.00
25 mg
¥ 1,260.00
50 mg
¥ 2,100.00
100 mg
¥ 3,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Gambogic acid是从藤黄汉树中分离出的天然产物。藤黄酸激活半胱氨酸蛋白酶,EC50为0.78-1.64μM,并竞争性抑制Bcl-XL,Bcl-2,Bcl-W,Bcl-B,Bfl-1和Mcl-1,IC50为1.47、1.21、2.02、0.66、1.06和 分别为0.79μM。
Targets
Target Value
Bcl-wIC50: 0.02μM
Bcl-BIC50: 0.66μM
Mcl-1IC50: 0.79μM
Bfl-1IC50: 1.06μM
Bcl-2IC50: 1.21μM
Bcl-xLIC50: 1.47μM
CaspaseEC50<1.64μM
In vitro (25°C) DMSO 97 mg/mL (154.27 mM)
Water Insoluble
Ethanol 97 mg/mL (154.27 mM)
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.9 mL 79.52 mL 159.05 mL
0.5 mM 3.18 mL 15.9 mL 31.81 mL
1 mM 1.59 mL 7.95 mL 15.9 mL
5 mM 0.32 mL 1.59 mL 3.18 mL

*The above data is based on the productmolecular weight 628.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11988
作用机制 Inhibitor (抑制剂)
M. Wt 628.75
Formula C38H44O8
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 2752-65-0
SMILES CC(=CCC[C@@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[C@@H]5C[C@@H]6[C@@]4(O3)[C@](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C

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